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Ecofriendly Synthesis of Ribociclib Intermediate Using Regioselective Hydrodechlorination and DMAP Catalyzed Ester Hydrolysis

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Abstract

This work reports the execution of Ecofriendly methods for the synthesis of Ribociclib precursor. Hazardous solvent free methodologies were optimized by using non hazardous and renewable solvents such as EtOH and DMSO. Highly abundant and biologically relavent Zinc metal was employed for Hydrodechlorination reaction along with Recommended solvent EtOH. DMAP catalyzed Ester hydrolysis reaction was performed using recommended solvent EtOH instead of MeOH. Amidation reaction was optimized using DMSO solvent instead of hazardous solvents such as DMF or NMP.

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Acknowledgements

The Start-Up Research Grant [F.20-1(28)/2012 9BSR)] funded by Faculty Research Promotion Schemes (FRPS) of the University Grants Commission (UGC)-India.

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Authors and Affiliations

  1. Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Odisha, 768018, India

    Allu Udayasri, Manchikanti M. Chandrasekhar & D. S. Ramakrishna

  2. Department of Physics, Veer Surendra Sai University of Technology, Burla, Odisha, 768018, India

    P. Lakshmi Praveen

  3. Prodev Pharma (OPC) Pvt. Ltd, ALEAP Industrial Estate, Hyderabad, 500090, India

    M. V. N. Brahmeswararao & Ganesh Varanasi

Authors
  1. Allu Udayasri
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  2. Manchikanti M. Chandrasekhar
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  3. M. V. N. Brahmeswararao
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  4. Ganesh Varanasi
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  5. P. Lakshmi Praveen
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  6. D. S. Ramakrishna
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Correspondence to D. S. Ramakrishna.

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Udayasri, A., Chandrasekhar, M.M., Brahmeswararao, M.V.N. et al. Ecofriendly Synthesis of Ribociclib Intermediate Using Regioselective Hydrodechlorination and DMAP Catalyzed Ester Hydrolysis. Top Catal 65, 1669–1674 (2022). https://doi.org/10.1007/s11244-022-01602-9

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