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Voltammetric Determination of Ceftizoxime by a Carbon Paste Electrode Modified with Ionic Liquid and Cu (Him)2 Nanoparticles

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Abstract

Ceftizoxime (CFX) is used to reduce the infection caused by both gram-negative and gram-positive bacteria. In this report, a novel electrochemical sensor for CFX comprising a Cu(Him)2 nanoparticles and ionic liquid (IL) hybride modified carbon paste electrode (CPE) has been developed. The structural properties of Cu(Him)2 nanoparticles was characterized using energy-dispersive X-ray spectroscopy (EDX) analyses, X-ray diffraction (XRD), and field emission scanning electron microscopy (FESEM). The results illustrate that Cu(Him)2/ILCPE exhibits an excellent electrocatalytic effect in the electrooxidation of CFX that leads to a considerable improvement in the corresponding anodic peak current. Under the best experimental conditions, the sensor exhibited a linear response to CFX from 2.0 to 1000.0 μM, with a limit of detection (LOD) of 0.5 nM. Finally, this also allows the development of a highly sensitive voltammetric sensor for the determination of CFX in pharmaceutical and biological samples.

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Authors and Affiliations

  1. Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

    Somayeh Tajik

  2. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hadi Beitollahi

  3. Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, 76175-133, Kerman, Iran

    Mahboobeh Shahsavari & Iran Sheikhshoaie

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  1. Somayeh Tajik
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  2. Hadi Beitollahi
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  4. Iran Sheikhshoaie
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Correspondence to Hadi Beitollahi.

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Tajik, S., Beitollahi, H., Shahsavari, M. et al. Voltammetric Determination of Ceftizoxime by a Carbon Paste Electrode Modified with Ionic Liquid and Cu (Him)2 Nanoparticles. Top Catal 65, 595–603 (2022). https://doi.org/10.1007/s11244-021-01469-2

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