Topics in Catalysis

, Volume 60, Issue 8, pp 545–553 | Cite as

Stereoselective Carboperfluoroalkylation of Internal Alkynes: Mechanistic Insights

Original Paper


A Pd-catalyzed difunctionalization of internal alkynes combining boronic acids and perfluoroalkyl iodides under mild conditions is described here. Tetrasubstituted olefins containing perfluoroalkyl groups are synthesized in high yields in a regio- and stereoselective manner. Mechanistic studies have been carried out to shed light on the nature of the likely intermediates involved in these transformations.


Perfluoroalkyl halides Alkynes Radicals Boron Difunctionalization 



We thank the European Research Council (ERC Starting Grant Agreement No. 307948) for financial support.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Zhaodong Li
    • 1
  • Estíbaliz Merino
    • 1
  • Cristina Nevado
    • 1
  1. 1.Department of ChemistryUniversity of ZurichZurichSwitzerland

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