Stereoselective Carboperfluoroalkylation of Internal Alkynes: Mechanistic Insights
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A Pd-catalyzed difunctionalization of internal alkynes combining boronic acids and perfluoroalkyl iodides under mild conditions is described here. Tetrasubstituted olefins containing perfluoroalkyl groups are synthesized in high yields in a regio- and stereoselective manner. Mechanistic studies have been carried out to shed light on the nature of the likely intermediates involved in these transformations.
KeywordsPerfluoroalkyl halides Alkynes Radicals Boron Difunctionalization
We thank the European Research Council (ERC Starting Grant Agreement No. 307948) for financial support.