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Strategies for Improving the Catalytic Performance of an Enzyme in Ionic Liquids

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Abstract

As media for an enzymatic reaction, ionic liquids (ILs) have many advantages over conventional molecular organic solvents, but some drawbacks still remain unsolved. In this review, we focus our attention on the various strategies that have been tried in recent years for improving the enzymatic performance in ILs. For clarity, this review is divided into several parts based on the hydrophilicity/hydrophobicity of ILs. For hydrophobic ILs, we put the emphasis on the construction of new macroscopically homogenous but microscopically heterogenous water-in-IL microemulsion systems and the catalytic performance of solubilized enzymes in them. For hydrophilic ILs, we highlight the enzyme performance related Hofmeister anions or cations series and the surface active effect of ILs.

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Abbreviations

[Bpy]+ :

1-Butylpyridinium

[Bmim]+ :

1-Butyl-3-methylimidazolium

[Bmpi]+ :

1-Butyl-1-methylpiperidinium

[Bu4N]+ :

Tetrabutylammonium

[Bu3NH]+ :

Tributylammonium

[Bmpy]+ :

1-Butyl-1-methylpyridinium

[BmPyrr]+ :

1-Butyl-1-methylpyrrolidinium

[Chol]+ :

Cholinium

[Cnmim]+ :

1-Alkyl-3-methylimidazolium

[Emim]+ :

1-Ethyl-3-methylimidazolium

[EtNH3]+ :

Ethylammonium

[Et3NH]+ :

Triethylammonium

[Gdm]+ :

Guanidinium

[Hmim]+ :

1-Hexyl-3-methylimidazolium

[HOPmim]+ :

1-(3-Hydroxypropyl)-3-methylimidazolium

[Mmim]+ :

1-Methyl-3-methylimidazolium

[Me4N]+ :

Tetramethylammonium

[Me3NH]+ :

Trimethylammonium

[Omim]+ :

1-Octyl-3-methylimidazolium

[Pmim]+ :

1-Propyl-3-methylimidazolium

[DBP]− :

Dibutyl phosphate

[DCA]− :

Dicyanimide

[DMP]− :

Dimethyl phosphate

[DHP]− :

Dihydrogen phosphate

[EtSO4]− :

Ethylsulfate

[MeSO3]− :

Methanesulfonate

[MeSO4]− :

Methylsulfate

[MeO(H)PO2]− :

Methylphosphonate

[NTf2]− :

Bis(trifluoromethanesulfonyl)imide

[TfO]− :

Trifluoromethanesulfonate

[TMA]− :

Trimethyl acetate

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Acknowledgments

The authors gratefully acknowledge the financial support from State Key Laboratory of Microbial Technology of China, the National Natural Science Foundation of China (20973103 and 21173133) and the National Basic Research Program of China (2011CB707400).

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Authors and Affiliations

  1. Key Laboratory of Colloid & Interface Chemistry of the Education Ministry of China, Jinan, China

    Xinxin Yu, Yanwen Sun, Luyan Xue & Xirong Huang

  2. State Key Laboratory of Microbial Technology of China, Shandong University, No. 27 Shanda Nanlu, Jinan, 250100, China

    Xirong Huang & Yinbo Qu

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  1. Xinxin Yu
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  2. Yanwen Sun
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  3. Luyan Xue
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  4. Xirong Huang
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Correspondence to Xirong Huang.

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Yu, X., Sun, Y., Xue, L. et al. Strategies for Improving the Catalytic Performance of an Enzyme in Ionic Liquids. Top Catal 57, 923–934 (2014). https://doi.org/10.1007/s11244-014-0253-0

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