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Synthesis, characterization and antileishmanial activity of copper(II) and zinc(II) complexes with diamine ligands

Transition Metal Chemistry volume 47, pages 147–156 (2022)Cite this article

Abstract

A new set of copper- and zinc-diamine (N-alkylated (L1) and N,N'-dialkylated (L2)) complexes, [Cu(L1)2(NO3)2] (1), [Cu(L1)2(Cl)2].5H2O (2), [Cu(L2)2(NO3)2] (3), [Cu(L2)2(Cl)2] (4), [Zn(L1)2(C2H3O2)2] (5), [Zn(L1)2(Cl)2] (6), [Zn(L2)2(C2H3O2)2] (7), [Zn(L2)2(Cl)2] (8) were prepared by a reaction of the N-alkylated (L1) and N,N'-dialkylated (L2) with their respective copper and zinc salts under mild conditions. The metal complexes were fully characterized by physicochemical and spectroscopic methods. All new metal compounds exhibited significant biological activity against Leishmania amazonensis promastigotes when compared to the free ligands (L1 and L2).

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Acknowledgements

The authors are grateful to Mr. Rodrigo Manoel da Silva Justo for the determinations of CHN and Dr. David Bátka for text editing. This work was supported by the Brazilian funding agencies: CAPES, CNPq and FAPEMIG. CASRC thanks FAPEMIG for her master's scholarship.

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Authors and Affiliations

  1. Laboratorio de Química Bioinorgânica e Catálises (LaQBIC), Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil

    Camila A. S. R. Condé & Maribel Navarro

  2. Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil

    Mauro V. De Almeida

  3. Núcleo Multidisciplinar de Pesquisa em Biologia (NUMPEX-Bio), Campus UFRJ-Duque de Caxias Prof. Geraldo Cidade, Duque de Caxias, Brasil

    Gabrielle dos Santos Da Silva, Milena Barenco Pires de Abreu Sodré & Juliany Cola Fernandes Rodrigues

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  1. Camila A. S. R. Condé
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  2. Mauro V. De Almeida
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  3. Gabrielle dos Santos Da Silva
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Correspondence to Maribel Navarro.

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Condé, C.A.S.R., De Almeida, M.V., Da Silva, G.d. et al. Synthesis, characterization and antileishmanial activity of copper(II) and zinc(II) complexes with diamine ligands. Transit Met Chem 47, 147–156 (2022). https://doi.org/10.1007/s11243-022-00495-7

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  • DOI: https://doi.org/10.1007/s11243-022-00495-7