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Synthesis, characterization and antileishmanial activity of copper(II) and zinc(II) complexes with diamine ligands

Abstract

A new set of copper- and zinc-diamine (N-alkylated (L1) and N,N'-dialkylated (L2)) complexes, [Cu(L1)2(NO3)2] (1), [Cu(L1)2(Cl)2].5H2O (2), [Cu(L2)2(NO3)2] (3), [Cu(L2)2(Cl)2] (4), [Zn(L1)2(C2H3O2)2] (5), [Zn(L1)2(Cl)2] (6), [Zn(L2)2(C2H3O2)2] (7), [Zn(L2)2(Cl)2] (8) were prepared by a reaction of the N-alkylated (L1) and N,N'-dialkylated (L2) with their respective copper and zinc salts under mild conditions. The metal complexes were fully characterized by physicochemical and spectroscopic methods. All new metal compounds exhibited significant biological activity against Leishmania amazonensis promastigotes when compared to the free ligands (L1 and L2).

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Acknowledgements

The authors are grateful to Mr. Rodrigo Manoel da Silva Justo for the determinations of CHN and Dr. David Bátka for text editing. This work was supported by the Brazilian funding agencies: CAPES, CNPq and FAPEMIG. CASRC thanks FAPEMIG for her master's scholarship.

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Correspondence to Maribel Navarro.

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Condé, C.A.S.R., De Almeida, M.V., Da Silva, G.d. et al. Synthesis, characterization and antileishmanial activity of copper(II) and zinc(II) complexes with diamine ligands. Transit Met Chem 47, 147–156 (2022). https://doi.org/10.1007/s11243-022-00495-7

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  • DOI: https://doi.org/10.1007/s11243-022-00495-7