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Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids

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Abstract

Six Schiff base compounds have been prepared from the condensation of o-vanillin, 2,3-dihydroxybenzaldehyde and 2,3,4-trihydroxybenzaldehyde with 4-aminosalicylic acid and 5-aminosalicylic acid (5-ASA). Addition of these Schiff bases to [Pd(OAc)2] afforded the corresponding bis(salicylaldiminato)palladium(II) complexes in moderate to excellent yields. All new palladium complexes have been characterized fully using standard spectroscopic methods, elemental analyses and a single-crystal X-ray diffraction study in the case of 2e, the palladium complex containing Schiff base ligands derived from 5-ASA and 2,3-dihydroxybenzaldehyde. All derivatives of 5-ASA were examined for potential antimicrobial activities against two species of fungi, Aspergillus niger and Saccharomyces cerevisiae, as well as two species of bacteria, Bacillus cereus (Gram-positive) and Pseudomonas aeruginosa (Gram-negative).

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Acknowledgements

Thanks are gratefully extended to Mount Allison University, Saint Mary’s University, and the Canada Research Chair Program (S.A.W.) for financial support. We also thank Cuthumb Durant (Mount Allison University) for his expert technical assistance and anonymous reviewers thanked for their helpful comments.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

    Jennifer A. Klaus, Muyang Zhou, Alexander M. Warman, Adam Palayew, Patrick T. Gormley, B. Ninh Khuong, Christopher M. Vogels & Stephen A. Westcott

  2. Department of Biology, Mount Allison University, Sackville, NB, E4L 1G7, Canada

    Taylor M. Brooks & Felix J. Baerlocher

  3. Department of Chemistry, Saint Mary’s University, Halifax, NS, B3H 3C3, Canada

    Alex J. Veinot & Jason D. Masuda

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  1. Jennifer A. Klaus
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Correspondence to Stephen A. Westcott.

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Klaus, J.A., Brooks, T.M., Zhou, M. et al. Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids. Transit Met Chem 42, 263–271 (2017). https://doi.org/10.1007/s11243-017-0130-3

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  • DOI: https://doi.org/10.1007/s11243-017-0130-3

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