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Synthesis of a palladium(II) complex of a N-heterocylic carbene via transmetalation: crystal structure and antibacterial studies

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Abstract

An Ag(I)-N-heterocylic carbene (NHC) complex, [Ag(L)2]PF6 (L = 1-(2′-methylbenzyl)-3-(2″-propyl)benzimidazolium), was used as a transfer agent for the synthesis of a Pd(II)–NHC complex, formulated as [PdCl(L)2(MeCN)]PF6 (Pd1). The complex Pd1 was characterized by 1H and 13C NMR, FTIR spectroscopy and elemental analysis. Single crystal X-ray diffraction analysis reveals that the Pd(II) atom has a square planar geometry. This complex was screened for its antibacterial potential against the Gram-negative bacteria Escherichia coli (ATCC 25922) and the Gram-positive bacteria Staphylococcus aureus (ATCC 12600). These results are compared with those obtained for a standard antibiotic, ampicillin, and also the corresponding Ag(I)–NHC complex.

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Acknowledgments

This work was supported by the RUI Grant 1001/PKIMIA/811260.

Author information

Correspondence to Mohd R. Razali.

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Haque, R.A., Haziz, U.F.M., Amirul, A.A. et al. Synthesis of a palladium(II) complex of a N-heterocylic carbene via transmetalation: crystal structure and antibacterial studies. Transit Met Chem 41, 775–781 (2016). https://doi.org/10.1007/s11243-016-0078-8

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Keywords

  • Minimum Inhibitory Concentration
  • Carbene
  • Benzimidazolium
  • Disc Diffusion Method
  • Minimum Bactericidal Concentration