Skip to main content
SpringerLink
Log in

Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity

  • Published:
Transition Metal Chemistry Aims and scope Submit manuscript

Abstract

Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1–L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation–mass spectrometry (ESI–MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02–45.27 μM, and IC50 range of 10.03–68.54 μM for the KYSE450 cell lines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dilworth JR, Howe SD, Hutson AJ, Miller JR, Silver J, Thomson RM, Harman M, Hursthouse MB (1994) J Chem Soc Dalton Trans (24):3553–3562

  2. Dilworth JR, Hutson AJ, Lewis JS, Miller JR, Zheng Y, Chen Q, Zubieta J, (1996) J Chem Soc Dalton Trans (6):1093–1104

  3. Dilworth JR, Miller JR, Wheatley N, Baker MJ, Sunley G, (1995) J Chem Soc Chem Commun (15):1579–1581

  4. Kapteijn GM, Spee MPR, Grove DM, Kooijman H, Spek AL, van Koten G (1996) Organometallics 15:1405

    Article  CAS  Google Scholar 

  5. Barbaro P, Bianchini C, Laschi F, Midollini S, Moneti S, Scapacci G, Zanello P (1994) Inorg Chem 33:1622

    Article  CAS  Google Scholar 

  6. Stoccoro S, Chelucci G, Zucca A, Cinellu MAG, Minghetti G Manassero J, (1996) J Chem Soc Dalton Trans (7):1295–1299

  7. Wehman P, van Donge HMA, Hagos A, Kamer PCJ, van Leeuven PWNM (1997) J Organomet Chem 535:183

    Article  CAS  Google Scholar 

  8. Bacchi A, Carcelli M, Costa M, Leporati A, Leporati E, Pelagatti P, Pelizzi C, Pelizzi G (1997) J Organomet Chem 535:107

    Article  CAS  Google Scholar 

  9. Gao J-X, Ikariya T, Noyoro R (1996) Organometallics 15:1087

    Article  CAS  Google Scholar 

  10. Brunner H, Fusrt J (1994) Inorg Chim Acta 220:63

    Article  CAS  Google Scholar 

  11. Rauchfuss TB (1978) J Organomet Chem 162:C19

    Article  CAS  Google Scholar 

  12. Jeffery JC, Rauchfuss TB, Tucker PA (1980) Inorg Chem 19:3306

    Article  CAS  Google Scholar 

  13. Faraglia G, Fregona D, Sitran S, Giovagnini L, Marzano C, Baccichetti F, Casellato U, Graziani R (2001) J Inorg Biochem 83:31

    Article  CAS  Google Scholar 

  14. Gill DS (1984) In: Hacker MP, Douple EB, Krakoff IH (eds) Platinum coordination complexes in cancer chemotherapy. Nijhoff, Boston, p 267

    Chapter  Google Scholar 

  15. Chatt J, Vallarino LM, Venanzi LM (1957) J Chem Soc Part V (678):3413–3416

  16. Bailey CT, Linsesky GCJ (1985) J Chem Edu 62:896

    Article  CAS  Google Scholar 

  17. Mogorosi MM, Mahamo T, Moss JR, Mapolie SF, Slootweg JC, Lammertsma K, Smith GS (2011) J Organomet Chem 696:3585–3592

    Article  CAS  Google Scholar 

  18. Barbour LJ (2001) X-Seed: a software tool for supramolecular crystallography. J Supromol Chem 1:189

    Article  CAS  Google Scholar 

  19. Ghilardi CA, Midollini S, Moneti S, Orlandini A, Scapacci G (1992) J Chem Soc Dalton Trans 23:3371–3376

    Article  Google Scholar 

  20. Sanchez G, Serrano JL, Moral MA, Perez J, Molins E, Lopez G (1999) Polyhedron 18:3057

    Article  CAS  Google Scholar 

  21. Ankersmit HA, Bjorn HL, Kooijman H, Spek AL, Vrieze K, van Koten G (1996), Inorga Chim Acta, 252:141–155

    Google Scholar 

  22. Koprowski M, Sebastian RM, Maraval V, Zablocka M, Cadierno V, Donnadieu B, Igau A, Caminade AM, Majoral JP (2002) Organometallics 21:4680

    Article  CAS  Google Scholar 

  23. Coleman KS, Green MLH, Pascu SI, Rees NH, Cowley AR, Rees LHJ (2001) Chem Soc Dalton Trans (22):3384–3395

  24. Pascu SI, Coleman KS, Cowley AR, Green MLH, Rees NH (2005) New J Chem 29:385

    Article  CAS  Google Scholar 

  25. Chiririwa H, Meijboom R, Omondi B (2011) Acta Cryst E67:m608–m609

    CAS  Google Scholar 

  26. Chiririwa H, Meijboom R (2011) Acta Cryst E67:m1498

    CAS  Google Scholar 

Download references

Acknowledgments

Financial support from the University of Cape Town, the National Research Foundation of South Africa, CANSA, Project AuTEK (Mintek and Harmony Gold, South Africa) and a donation of metal salts from the Anglo Platinum Corporation is gratefully acknowledged.

Author information

Authors and Affiliations

  1. Department of Chemistry, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa

    Haleden Chiririwa & John R. Moss

  2. Division of Medical Biochemistry, University of Cape Town, Private Bag X3, Observatory, 7935, South Africa

    Haleden Chiririwa & Denver Hendricks

  3. Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, Auckland Park, PO Box 524, Johannesburg, 2006, South Africa

    Haleden Chiririwa, Reinout Meijboom & Alfred Muller

Authors
  1. Haleden Chiririwa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John R. Moss
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Denver Hendricks
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Reinout Meijboom
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alfred Muller
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Haleden Chiririwa.

Additional information

John R. Moss: Deceased.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chiririwa, H., Moss, J.R., Hendricks, D. et al. Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity. Transition Met Chem 38, 165–172 (2013). https://doi.org/10.1007/s11243-012-9674-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11243-012-9674-4

Keywords

Search

Navigation