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Synthesis, characterization, and antibacterial activities of copper(I) bromide complexes of thioureas: X-ray structure of [Cu(Metu)4]Br

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Abstract

Copper(I) complexes of thioureas having the general formulae [CuLnBr] and [CuLn]Br [where, n = 1 − 4 and L = thiourea (Tu), N-methylthiourea (Metu), N-ethylthiourea (Ettu), N,N′-dipropylthiourea (Dprtu), N,N′-dibutylthiourea (Dbtu) or N,N′-diphenylthiourea (Dphtu)] were prepared and characterized by elemental analysis, IR, and NMR (1H and 13C) spectroscopy. The crystal structure of one of them, [Cu(Metu)4]Br (1), was determined by X-ray crystallography. The X-ray structure of 1 describes a tetrahedral geometry around copper(I) with all Metu ligands binding through sulfur atoms. An upfield shift in the 13C NMR and downfield shift in the 1H NMR spectra are consistent with the thione coordination to copper(I). Antimicrobial activities of the complexes were evaluated by the minimum inhibitory concentration method. The results showed that only [Cu(Ettu)3Br] was effective in inhibiting the growth of all the tested organisms (gram-positive, gram-negative bacteria, and Candida sp.), while the other complexes were not effective against all the organisms.

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Authors and Affiliations

  1. Department of Chemistry, Government College University, Lahore, 54000, Pakistan

    Muhammad Mufakkar & Abdul Waheed

  2. Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran, 31261, Saudi Arabia

    Anvarhusein A. Isab

  3. Lehrstuhl für Anorganische Chemie, Institut für Chemie, Technische Universität Chemnitz, Straße der Nationen 62, 09111, Chemnitz, Germany

    Tobias Rüffer & Heinrich Lang

  4. Department of Chemistry, University of Engineering and Technology, Lahore, 54890, Pakistan

    Saeed Ahmad

  5. Department of Zoology, University of the Punjab, Lahore, Pakistan

    Najma Arshad

Authors
  1. Muhammad Mufakkar
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  2. Anvarhusein A. Isab
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  3. Tobias Rüffer
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  4. Heinrich Lang
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  5. Saeed Ahmad
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  6. Najma Arshad
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  7. Abdul Waheed
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Correspondence to Saeed Ahmad.

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Mufakkar, M., Isab, A.A., Rüffer, T. et al. Synthesis, characterization, and antibacterial activities of copper(I) bromide complexes of thioureas: X-ray structure of [Cu(Metu)4]Br. Transition Met Chem 36, 505–512 (2011). https://doi.org/10.1007/s11243-011-9496-9

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  • DOI: https://doi.org/10.1007/s11243-011-9496-9

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