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Synthesis, crystal structure, and DNA cleavage activity of a dinuclear nickel(II) complex with a macrocyclic ligand

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Abstract

A new Ni(II) complex, namely [Ni2(OAc)L]·ClO4·H2O, was synthesized by [2 + 2] cyclo-condensation between 2,6-diformyl-4-methylphenol and N,N-bis(3-aminopropyl)-4-methoxybenzylamine (amba) in the presence of nickel(II) and characterized by spectroscopy, elemental analysis, and X-ray single crystal diffraction. The interactions of the complex with DNA have been measured by spectroscopy and viscosity measurements. Absorption spectroscopic investigation reveals intercalative binding of the Ni(II) complex with DNA, with a binding constant of 2.6 × 104 M−1. Fluorescence spectroscopy shows that the Ni(II) complex can displace ethidium bromide and bind to DNA, with a quenching constant of 7.57 × 103 M−1. The appearance of increased CD bands near 245 and 275 nm gives evidence for effective complex DNA binding. The agarose gel electrophoresis studies show that the complex displays effective DNA cleavage activity in the absence of any external agents.

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Acknowledgments

This work was supported by National Nature Science Foundation of China (No. 20971102, 21002076), the foundation for midlife and youth excellent innovation group of Hubei Province, China (No. T200802), the key foundation of the Education Department of Hubei Province, China (No. D20081503).

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Authors and Affiliations

  1. Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, 430073, Wuhan, People’s Republic of China

    Hong Hu, Yunfeng Chen, Hong Zhou & Zhiquan Pan

  2. State Key Laboratory of Coordination Chemistry, Nanjing University, 210093, Nanjing, People’s Republic of China

    Zhiquan Pan

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  1. Hong Hu
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  2. Yunfeng Chen
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Correspondence to Zhiquan Pan.

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Hu, H., Chen, Y., Zhou, H. et al. Synthesis, crystal structure, and DNA cleavage activity of a dinuclear nickel(II) complex with a macrocyclic ligand. Transition Met Chem 36, 395–402 (2011). https://doi.org/10.1007/s11243-011-9482-2

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  • DOI: https://doi.org/10.1007/s11243-011-9482-2

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