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Copper(II) complexes with N-(2-hydroxyethyl)-2-iminodiacetic acid and imidazoles: crystal structure, spectroscopic studies and superoxide dismutase activity

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Abstract

Two new copper(II) complexes, [Cu(Hhida)(BenzImH)]·H2O (1) and [Cu(Hhida)(EtImH)]·2H2O (2) have been synthesized by the interaction of basic copper carbonate with N-(2-hydroxyethyl)-2-aminodiacetic acid (Hhida2−) and benzimidazole (BenzImH) or (2-ethylimidazole (EtImH)). The structures of both complexes were studied by single crystal X-ray diffraction. The geometry around the copper(II) atom can be best described as distorted square pyramidal as indicated by the value of the trigonal index τ = 0.32 for (1) and 0.21 for (2). Spectroscopic and electrochemical studies were performed in order to correlate structural features of the complexes with their superoxide scavenger activity. The ability of the complexes to scavenge superoxide anions was also evaluated.

Graphical Abstract

Two new copper(II) complexes [Cu(Hhida)(BenzImH)]·H2O (1) and [Cu(Hhida)(EtImH)]·2H2O (2) have been synthesized by the interaction of basic copper carbonate with N-(2-hydroxyethyl)-2-aminodiacetic acid (Hhida2−) and benzimidazole(BenzImH) (2-ethylimidazole(EtImH)). Spectroscopic and electrochemical studies were performed in order to correlate structural feature of the complexes (Figs. 1 and 2) with their superoxide scavenger activity.

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Acknowledgments

Our grateful thanks are due to the National Diffraction Facility, X-ray Division, and RSIC (SAIF), IIT Mumbai for single crystal data collection and epr measurements, respectively. The Head RSIC (SAIF), Central Drug Research Institute, Lucknow is also thankfully acknowledged for providing analytical and spectral facilities. Financial assistance from UGC [Scheme no. 36-28/2008 (SR)] and CSIR [Scheme no. 01 (2094)/07/EMR-II], New Delhi are also thankfully acknowledged.

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  1. Department of Chemistry, A.P.S. University, Rewa, MP, 486003, India

    Ram N. Patel, Anurag Singh, Krishna K. Shukla, Dinesh K. Patel & Vishnu P. Sondhiya

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  1. Ram N. Patel
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  2. Anurag Singh
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  3. Krishna K. Shukla
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Patel, R.N., Singh, A., Shukla, K.K. et al. Copper(II) complexes with N-(2-hydroxyethyl)-2-iminodiacetic acid and imidazoles: crystal structure, spectroscopic studies and superoxide dismutase activity. Transition Met Chem 35, 577–584 (2010). https://doi.org/10.1007/s11243-010-9366-x

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