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Synthesis, characterization and antibacterial activity of palladium(II) bromide complexes of thioamides; X-ray structure of [Pd(tetramethylthiourea)4]Br2

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Abstract

Palladium(II) bromide complexes of thioamides having the general formulae [PdL2Br2] and [PdL4]Br2 where L = Thiourea (Tu), Methylthiourea (Metu), Dimethylthiourea (Dmtu), Tetramethylthiourea (Tmtu), Imidazolidine-2-thione (Imt), Mercaptopyridine (Mpy), Mercaptopyrimidine (Mpm) and Thionicotinamide (Tna) were prepared by reacting K2[PdCl4] with KBr and the corresponding thioamides. The complexes were characterized by elemental analysis, IR and NMR spectroscopy, and one of them, [Pd(Tmtu)4]Br2 (1) by X-ray crystallography. The crystal structure of 1 shows a square-planar coordination environment around the Pd(II) atoms with the average cis and trans S–Pd–S bond angles of 90.0° and 180.0°, respectively. The synthesized complexes were screened for antibacterial effects, and the results showed that the complexes exhibit significant activities against both gram positive and gram negative bacteria.

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Acknowledgments

Financial support from Pakistan Council for Science and Technology, Islamabad, Pakistan is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan

    Shafqat Nadeem, Muhammad Khawar Rauf, Syed Ahmed Tirmizi & Maliha Asma

  2. Institut für Anorganische Chemie, J. W. Goethe-Universität Frankfurt Max-von-Laue-Strasse 7, 60438, Frankfurt/Main, Germany

    Michael Bolte

  3. Department of Chemistry, University of Engineering and Technology, Lahore, 54890, Pakistan

    Saeed Ahmad

  4. Microbiology Research Laboratory, Department of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

    Abdul Hameed

Authors
  1. Shafqat Nadeem
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  2. Muhammad Khawar Rauf
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  3. Michael Bolte
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  4. Saeed Ahmad
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  5. Syed Ahmed Tirmizi
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  6. Maliha Asma
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  7. Abdul Hameed
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Correspondence to Saeed Ahmad.

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Nadeem, S., Rauf, M.K., Bolte, M. et al. Synthesis, characterization and antibacterial activity of palladium(II) bromide complexes of thioamides; X-ray structure of [Pd(tetramethylthiourea)4]Br2 . Transition Met Chem 35, 555–561 (2010). https://doi.org/10.1007/s11243-010-9363-0

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  • DOI: https://doi.org/10.1007/s11243-010-9363-0

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