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Transition metal complexes of a potential anticancer quinazoline ligand

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Abstract

A new heterocycle, namely 2-(furyl)-3-(furfuralimino)-1,2-dihydroquinazolin-4(3H)-one (ffdq) was formed by the condensation of 2-aminobenzoylhydrazide with furfural and characterized by physico-chemical, spectroscopic, and single crystal X-ray diffraction studies. A series of complexes of ffdq have been synthesized and characterized by physico-chemical, spectroscopic, and thermal studies. According to the i.r. and 1H-n.m.r. spectra ffdq behaves as a bidentate ligand coordinating through quinazoline oxygen and azomethine nitrogen. The FAB-mass spectrum of the Cd(II) complex indicates the monomeric nature of this complex. The X-band e.p.r. spectrum of the Cu(II) complex and thermal stabilities of the Co(II) and Ni(II) complexes are discussed.

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Acknowledgments

Authors are thankful to the Department of Inorganic and Physical Chemistry and Sophisticated Instrumentation Facility, Indian Institute of Science, Bangalore, Indian Institute of Technology, Bombay, and Central Drug Research Institute, Lucknow for recording crystal structure, 1H-n.m.r., e.p.r., and FAB-mass spectra, respectively. Thanks are also due to University Sophisticated Instrumentation Center, Karnatak University Dharwad for carrying out elemental analysis. One of the author (SAP) is thankful to Karnatak University Dharwad for award of University Research fellowship.

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Authors and Affiliations

  1. Department of Chemistry, Karnatak University, Dharwad, 580003, India

    Kalagouda B. Gudasi, Siddappa A. Patil & Manohar V. Kulkarni

  2. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India

    Munirathinam Nethaji

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  1. Kalagouda B. Gudasi
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  2. Siddappa A. Patil
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  3. Manohar V. Kulkarni
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  4. Munirathinam Nethaji
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Correspondence to Kalagouda B. Gudasi.

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Gudasi, K.B., Patil, S.A., Kulkarni, M.V. et al. Transition metal complexes of a potential anticancer quinazoline ligand. Transition Met Chem 34, 325–330 (2009). https://doi.org/10.1007/s11243-009-9198-8

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