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Synthesis, spectroscopic analysis and structure deduction of gold(III), palladium(II) and platinum(II) complexes with the tripeptide glycyl-l-phenylalanyl-glycine

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Abstract

The coordination behaviour of the tripeptide glycyl-l-phenylalanyl-glycine (H-Gly-Phe-Gly-OH) with Au(III), Pd(II), and Pt(II) in both solution and in the solid state has been investigated experimentally. In addition, quantum chemical calculations have been carried out with a view to obtain the structures and spectroscopic properties of the ligand and its complexes. Both in solution and in the solid state the tripeptide interacts in a tetradentate manner with the Au(III) and Pd(II) ions through the NH2, two deprotonated amide N atoms and the COO−group, forming [Au(H-Gly-Phe-Gly-OH)H−2)] × H2O and [Pd(H-Gly-l-Phe-Gly-OH)H−2)]Na × H2O complexes. The MN3O chromophores are calculated to be near planar. Interaction with cisplatin leads to the formation of a mononuclear complex with tridentate coordination of the ligand by NH2 and two N- atoms from the deprotonated amide groups ([Pt(H-Gly-l-Phe-Gly-OH)H−2)NH3] × 2H2O). The fourth coordination position of the Pt(II) is occupied by an NH3 ligand. The PtN4 chromophore is flat with a deviation from planarity of 0.3°.

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Acknowledgments

B.K. wishes to thank the Alexander von Humboldt Foundation for the Fellowship and the Prof. W.S. Sheldrick for the useful and creative discussion. T.K. and M.S. wish to thank the DAAD for a grant within the priority program “Stability Pact South-Eastern Europe” and the Alexander von Humboldt Foundation.

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Authors and Affiliations

  1. Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, Universitätsstraße 150, 44780, Bochum, Germany

    Bojidarka B. Koleva

  2. Institut für Umweltforschung, Universität Dortmund, Otto-Hahn-Strasse 6, 44221, Dortmund, Germany

    Tsonko Kolev, Marc Lamshöft & Michael Spiteller

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  1. Bojidarka B. Koleva
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Correspondence to Bojidarka B. Koleva.

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Koleva, B.B., Kolev, T., Lamshöft, M. et al. Synthesis, spectroscopic analysis and structure deduction of gold(III), palladium(II) and platinum(II) complexes with the tripeptide glycyl-l-phenylalanyl-glycine. Transition Met Chem 33, 911–919 (2008). https://doi.org/10.1007/s11243-008-9132-5

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