Abstract
Antimalarial drugs such as chloroquine are beneficial agents in systemic lupus and rheumatoid arthritis. In this work, two new chloroquine diphosphate (CQDP) complexes containing Zn(II) and Au(III) of formula Zn(CQDP)(NO3)2 (1) and Au(CQDP)Cl3 (2), respectively, were synthesized and characterized by physico-chemical and spectroscopic methods. To examine their possible anti-inflammatory properties, the new derivatives were tested in the range from 1 to 100 μM on the respiratory burst of isolated human neutrophils (PMNs) as well as in whole blood. In isolated PMNs, complex 1 inhibited the isoluminol-enhanced chemiluminescence (IL-CL) only at the highest concentration tested, whereas in the whole blood assay, 10 μM of this complex was sufficient to significantly inhibit the luminol-enhanced chemiluminescence (L-CL). On the contrary, complex 2 dose-dependently inhibited the IL-CL but affected the L-CL only at 100 μM. In conclusion, both complexes are more active than CQDP and may be useful for future treatment of diseases resulting from exacerbated neutrophil functions.
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References
Bondeson J (1997) Gen Pharmacol 29:127
Labro MT, Babin-Chevaye C (1988) Antimicrob Agents Chemother 32:1124
Fontagne J, Roch-Arveiller M, Giroud JP et al (1989) Biomed Pharmacother 43:43
Appelberg R (2007) Trends Microbiol 15:87
Tintinger G, Steel HC, Anderson R (2005) Clin Exp Immunol 141:191
Navarro M, Vásquez F, Velásquez M et al (2002) Arzneimittelforschung 52:468
Navarro M, Goitia H, Silva P et al (2005) J Inorg Biochem 99:1630
Shaw CF (1999) Chem Rev 99:2589
Stern I, Wataha JC, Lewis JB et al (2005) Toxicol In Vitro 19:365
Wilkinson G (1987) Comprehensive coordination chemistry, 1st edn vol 5, chapter 51. Pergamon Press, Oxford
Dahlgren C, Karlsson AJ (1999) J Immunol Methods 232:3
Lundqvist H, Dahlgren C (1996) Free Rad Biol Med 20:785
Mahomed AG, Anderson R (2000) Inflammation 24:559
Marcon G, Messori L, Orioli P et al (2003) Eur J Biochem 270:4655
Eggleton P, Gargan R, Fisher DJ (1989) J Immunol Methods 121:105
Kroes BH, van den Berg AJ, Quarles van Ufford HC et al (1992) Planta Med 58:499
Acknowledgments
The authors wish to thank MSc Sara Pekerar, MSc Matilde Gomez, TSU Alberto Fuentes, Lic. Angel Higuera, and TSU Ibis Colmenares for their assistance.
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Navarro, M., Hernández, C., Vásquez, F. et al. Syntheses, characterization, and biological evaluation of new zinc-and gold-chloroquine diphosphate complexes. Transition Met Chem 33, 893–898 (2008). https://doi.org/10.1007/s11243-008-9129-0
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DOI: https://doi.org/10.1007/s11243-008-9129-0