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Synthesis, crystal structures and DNA-binding properties of two new mononuclear copper(II) complexes

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Abstract

Two mononuclear copper(II) complexes, [Cu(bpy)2(CH3OH)](pic)2 (1) and [Cu(Me2bpy)2(H2O)](pic)2 (2) (bpy = 2,2′-bipyridine; Me2bpy = 4,4′-dimethyl-2,2′-bipyridine; Hpic = 2,4,6-trinitrophenol), were synthesized and characterized by elemental analyses, conductivity measurements, IR, UV–Visible spectroscopy and single crystal X-ray analyses. Both complexes 1 and 2 are mononuclear compounds. The copper atom in complex 1 is in a distorted square pyramidal geometry with a CuN4O chromophore as revealed from the τ value (0.25), while the Cu(II) ion in complex 2 displays a distorted trigonal bipyramidal stereochemistry with τ = 0.72. Hydrogen bonding interactions and π–π stacking interactions link the mononuclear copper complex 1 or 2 into a 1D infinite chain. The interactions of the two mononuclear complexes with herring sperm DNA (HS-DNA) have been studied by UV–visible absorption titration, fluorescence titration and ethidium bromide (EB) displacement experiments. The results suggest that both complexes might bind to DNA by intercalation.

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Acknowledgements

This project was supported by the National Natural Science Foundation of China (No. 30672515) and the Ph.D. Program Foundation of Ministry of Education of China (No. 20060423005).

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Authors and Affiliations

  1. Marine Drug & Food Institute, Ocean University of China, Qingdao, Shandong, 266003, People’s Republic of China

    Yu-Lan Song, Yan-Tuan Li & Zhi-Yong Wu

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  1. Yu-Lan Song
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  2. Yan-Tuan Li
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  3. Zhi-Yong Wu
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Correspondence to Yan-Tuan Li.

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Song, YL., Li, YT. & Wu, ZY. Synthesis, crystal structures and DNA-binding properties of two new mononuclear copper(II) complexes. Transition Met Chem 33, 781–789 (2008). https://doi.org/10.1007/s11243-008-9111-x

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  • DOI: https://doi.org/10.1007/s11243-008-9111-x

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