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Studies on cytotoxic and DNA-binding properties of two ruthenium(II) complexes of a substituted phenanthroline ligand

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Abstract

Two chair ruthenium(II) complexes, Λ- and Δ-[Ru(bpy)2tFMPIP]2 + (bpy = bipyridyl; tFMPIP = (2′-trifluoromethylphenyl)-imidazo-[4,5-f]-[1, 10]-phenanthroline, Λ-1 and Δ-1) have been synthesized and characterized by elemental analysis, ESI-MS and 1H-NMR. The cytotoxicity of these complexes against human hepatocarcinoma cell line Bel-7402, human intestinal adenocarcinoma cell line HCT-8, and Human lung adenocarcinoma epithelial cell line A-549 have been investigated by colorimetric MTT (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl-1H-tetrazolium bromide) assay. Both Λ-1 and Δ-1 exhibit excellent inhibitory activity against the growth of Bel-7402 and HCT-8 cells. At dosage of 5 μg/cm3, the inhibition of Λ-1 and Δ-1 against human hepatocarcinoma cell line Bel-7402 is 85 and 85%, respectively. The studies on the DNA-binding properties of these complexes with Bel-7402 cell DNA by electronic spectra and steady state emission spectra, as well as circular dichlorism spectra show that there are detectable but subtle differences between Λ-1 and Δ-1, indicating the antitumor activity of these complexes is related to their DNA-binding behaviors.

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Acknowledgment

We are grateful to the Nature Science Foundation of Guangdong Province (04300624) and the Planned Item of Science and Technology of Guangdong Province (2007B031513004) for their financial supports.

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Authors and Affiliations

  1. The Pharmacy Department, Guangdong Pharmaceutical University, Guangzhou, 510006, P.R. China

    Wen-Jie Mei, Na Wang, Yun-Jun Liu, Yu-Zhuo Ma, Ding-Yong Wang & Bao-Xia Liang

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  1. Wen-Jie Mei
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Correspondence to Wen-Jie Mei.

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Mei, WJ., Wang, N., Liu, YJ. et al. Studies on cytotoxic and DNA-binding properties of two ruthenium(II) complexes of a substituted phenanthroline ligand. Transition Met Chem 33, 499–503 (2008). https://doi.org/10.1007/s11243-008-9071-1

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  • DOI: https://doi.org/10.1007/s11243-008-9071-1

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