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Synthesis, characterization and antiprotozoal studies of some metal complexes of antimalarial drugs

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Abstract

Metal complexes of the antimalarials trimethoprim (TMP), chloroquine (CQ), and pyrimethamine (pyrm) formulated as [Mn(TMP)Cl2(CH3OH)], [Co(TMP)2Cl2(CH3OH)], [Pt(CQ)2Cl2] and [Cu(pyrm)2(CH3COO)2] have been synthesized and characterized by elemental analysis, magnetic susceptibility measurements, IR and UV-Vis spectroscopy. The IR and electronic spectra are consistent with the proposed geometry for the complexes. The Mn(II) and Pt(II) complexes are four coordinate while the Cu(II) and Co(II) have octahedral geometry. The complexes were tested for in vitro activity against cultures of Trypanosoma cruzi, L. donovani, T. b. rhodesiense and the resistant strains of Plasmodium falciparum to determine their antiprotozoal activities and for their cytotoxicity with L-6 cells. The Pt(II) complex of chloroquine showed enhanced activity against the resistant strain of Plasmodium falciparum.

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Acknowledgements

The authors gratefully acknowledge the contribution of Prof. Reto Brun and Marcel Kaizer (Swiss Tropical Institute) and financial support of the National Research Foundation (South Africa) and the GMRDC, University of Fort Hare.

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Authors and Affiliations

  1. Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice, 5700, South Africa

    Peter A. Ajibade

  2. Department of Chemistry, University of Zululand, Private Bag X1001, Kwadlangezwa, 3886, South Africa

    Gabriel A. Kolawole

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  1. Peter A. Ajibade
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  2. Gabriel A. Kolawole
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Correspondence to Peter A. Ajibade.

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Ajibade, P.A., Kolawole, G.A. Synthesis, characterization and antiprotozoal studies of some metal complexes of antimalarial drugs. Transition Met Chem 33, 493–497 (2008). https://doi.org/10.1007/s11243-008-9070-2

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  • DOI: https://doi.org/10.1007/s11243-008-9070-2

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