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Synthesis, characterization, and DNA-binding properties of copper(II), cobalt(II), and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone

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Abstract

Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H2L), and its novel copper(II), cobalt(II), and nickel(II) complexes MHL · Cl · nH2O [M=Cu n = 3 (1), M=Co n = 2 (2), M=Ni n = 3.5 (3)] have been synthesized and characterized by elemental analysis, molar conductivity, spectroscopic, and thermal analysis. The interaction of these complexes with calf thymus DNA was investigated by UV absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry, and viscosity measurements. The results suggest that these complexes bind to DNA via an intercalation binding mode and their affinity to DNA follows the order of 3 > 1> 2.

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Acknowledgments

The authors thank the National Natural Science Foundation of China (20171019) for financial support.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P.R. China

    Zhi-hong Xu, Pin-xian Xi, Feng-juan Chen, Xiao-hui Liu & Zheng-zhi Zeng

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  1. Zhi-hong Xu
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  2. Pin-xian Xi
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  3. Feng-juan Chen
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  4. Xiao-hui Liu
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  5. Zheng-zhi Zeng
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Correspondence to Zheng-zhi Zeng.

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Xu, Zh., Xi, Px., Chen, Fj. et al. Synthesis, characterization, and DNA-binding properties of copper(II), cobalt(II), and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone. Transition Met Chem 33, 267–273 (2008). https://doi.org/10.1007/s11243-007-9038-7

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