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Synthesis and kinetic studies in aqueous solution on chromium(III) complexes with isocinchomeronic acid—potential new biochromium sources

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Abstract

The chromium(III) complexes with a new potential chromium transporting ligand—2,5-pyridinedicarboxylic acid (isocinchomeronic acid, icaH2):[Cr(icaH)3]0, [Cr(icaH)2 (H2O)2]+ and [Cr(icaH)(H2O)4]2+ (where icaH = N,O-bonded isocinchomeronic acid anion), have been obtained and characterized in solution. The [Cr(icaH)3]0 complex undergoes aquation in acidic media to the diaqua-product. Kinetics of this process was studied spectrophotometrically in the 0.1–1.0 M HClO4 range, at I = 1.0 M. The first aquation stage, the chelate-ring opening at the Cr–N bond, is a much faster than the second one. The rate laws are of the form: k obs = k 1 + k −1/Q 1[H+] and k obs = k 2 Q 2[H+]/(1 + Q 2[H+]), where k 1 and k 2 are the rate constants for the chelate-ring opening and the ligand liberation, respectively, k −1 is the rate constant of the chelate-ring closure, Q 1 and Q 2 are the protonation constants of the pyridine nitrogen and 5-carboxylate group in the one-end bonded intermediate, respectively. The results are discussed in terms of potential pharmaceutical application of the complex.

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References

  1. Petitfaux C, Fournaise R (1972) Bull Chim Frans 3:914

    Google Scholar 

  2. Borowiak-Resterna A, Szymanowska J, Voelkel A (1996) J Radioanal Nucl Chem Art 208:75

    Article  CAS  Google Scholar 

  3. Wasylina L, Kucharska E, Węgliński Z, Puszko A (1999) Chem Heterocycl Comp 35:186

    Google Scholar 

  4. Grigss DL, Heden P, Smith KET, Rademacher W (1991) Photochemistry 30:2513

    Article  Google Scholar 

  5. Goher MAS, Mak TCW (1994) Struct Chem 5:165

    Article  CAS  Google Scholar 

  6. Brzyska W, Ożga W (1996) Thermochim Acta 288:113

  7. Sengupta P, Gosh S, Mak TCW (2001) Polyhedron 20:975

    Article  CAS  Google Scholar 

  8. Choi K-Y, Chun KM, Suh I-H (2001) Polyhedron 20:57

    Article  CAS  Google Scholar 

  9. Basiuk EV, Basiuk VV, Gomez-Lara J, Toscano RA (2000) J Inclusion Phenom Macrocycl Chem 38:45

    Article  CAS  Google Scholar 

  10. Patrick BO, Stevens CL, Storr A, Thompson RC (2005) Polyhedron 24:2242

    Article  CAS  Google Scholar 

  11. Süss-Fink G, Cuervo LG, Therrien B, Stoeckli-Evans H, Shul’pin GB (2004) Inorg Chim Acta 357:475

    Article  Google Scholar 

  12. Liang Y, Hong M, Su W, Cao R, Zhang W (2001) Inorg Chem 40:4574

    Article  CAS  Google Scholar 

  13. Liang Y, Cao R, Su W, Hong M, Zhang W (2000) Angew Chem Int Ed 39:3304

    Article  CAS  Google Scholar 

  14. Min D, Yoon SS, Jung D-Y, Lee CY, Kim Y, Han WS, Lee SW (2001) Inorg Chim Acta 324:293

    Article  CAS  Google Scholar 

  15. Hong-Ling G, Cai C, Bin D, Wei S, Hai-Bin S, Peng C, Dao-Zheng L, Shi-Ping Y, Zong-Hui J (2005) J Mol Struct 738:105

    Article  Google Scholar 

  16. Shiu KB, Chen ZW, Liao FL, Wang SL (2003) Acta Crystallogr Struct Rep Online E59:1072

    Article  Google Scholar 

  17. Garcia-Zarracino R, Heopfl H (2005) J Am Chem Soc 127:3120

    Article  CAS  Google Scholar 

  18. Pan L, Frydek T, Sander MB, Huang X, Li J (2001) Inorg Chem 40:1271

    Article  CAS  Google Scholar 

  19. Heh JC-K, Gould ES (1978) Inorg Chem 17:3138

    Article  CAS  Google Scholar 

  20. Kita E, Gołembiewska K (2007) Transition Met Chem 32:56

    Google Scholar 

  21. Kita E, Szabłowicz M (2003) Trans Met Chem 28:698

    Google Scholar 

  22. Szabłowicz M, Kita E (2005) Trans Met Chem 30:623

    Google Scholar 

  23. Szabłowicz M, Kita E (2006) Trans Met Chem 31:220

    Google Scholar 

Download references

Acknowledgment

Hasan Marai wishes to thank to Libyan Government for the financial support of his studies in Poland.

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Correspondence to Ewa Kita.

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Kita, E., Marai, H. & Zając, K. Synthesis and kinetic studies in aqueous solution on chromium(III) complexes with isocinchomeronic acid—potential new biochromium sources. Transition Met Chem 33, 211–217 (2008). https://doi.org/10.1007/s11243-007-9025-z

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  • DOI: https://doi.org/10.1007/s11243-007-9025-z

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