Abstract
The chromium(III) complexes with a new potential chromium transporting ligand—2,5-pyridinedicarboxylic acid (isocinchomeronic acid, icaH2):[Cr(icaH)3]0, [Cr(icaH)2 (H2O)2]+ and [Cr(icaH)(H2O)4]2+ (where icaH = N,O-bonded isocinchomeronic acid anion), have been obtained and characterized in solution. The [Cr(icaH)3]0 complex undergoes aquation in acidic media to the diaqua-product. Kinetics of this process was studied spectrophotometrically in the 0.1–1.0 M HClO4 range, at I = 1.0 M. The first aquation stage, the chelate-ring opening at the Cr–N bond, is a much faster than the second one. The rate laws are of the form: k obs = k 1 + k −1/Q 1[H+] and k obs = k 2 Q 2[H+]/(1 + Q 2[H+]), where k 1 and k 2 are the rate constants for the chelate-ring opening and the ligand liberation, respectively, k −1 is the rate constant of the chelate-ring closure, Q 1 and Q 2 are the protonation constants of the pyridine nitrogen and 5-carboxylate group in the one-end bonded intermediate, respectively. The results are discussed in terms of potential pharmaceutical application of the complex.
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Acknowledgment
Hasan Marai wishes to thank to Libyan Government for the financial support of his studies in Poland.
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Kita, E., Marai, H. & Zając, K. Synthesis and kinetic studies in aqueous solution on chromium(III) complexes with isocinchomeronic acid—potential new biochromium sources. Transition Met Chem 33, 211–217 (2008). https://doi.org/10.1007/s11243-007-9025-z
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DOI: https://doi.org/10.1007/s11243-007-9025-z