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Synthesis, characterization and biological analysis of the complex [VO(Hdhp)2] (H2dhp = 2,3-dihydroxypyridine)

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Abstract

A new vanadium (IV) complex with the monoanion of 2,3-dihydroxypyridine (H2dhp), or 3-hydroxy-2-(1H)-pyridone, was synthesized, characterized by physicochemical techniques and tested biologically. The EPR data for the [VO(Hdhp)2] complex in DMF are: g x  = 1.9768, g y  = 1.9768 and g z  = 1.9390; A values (10−4 cm−1): A x , 59.4; A y//, 59.4; A z , 171.0. The νV=O band in the IR spectrum of the complex is at 986 cm−1. The complex is paramagnetic, with μeff = 1.65 BM (d1, spin-only) at 25 °C. The irreversible oxidation process [V(V)/V(IV)] of the [VO(Hdhp)2] complex, as revealed in a cyclic voltammogram, occurs at 876 mV. The calculated molecular structure of [VO(Hdhp)2] shows the vanadium(IV) center in a distorted square pyramidal environment, with the oxo ligand in the apical position and the oxygen donor atoms of the Hdhp ligands in the basal positions. The ability of [VO(Hdhp)2] to mimic insulin, and its toxicity to hepato-biliary functions, were investigated in streptozotocin-induced diabetic rats and it was concluded that the length of treatment and the amount of [VO(Hdhp)2] administered were effective in reducing experimental diabetes.

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Acknowledgments

We wish to thank the Foundation for the Development of the University of the State of São Paulo (FUNDUNESP), the Scientific Research Aid Program of the Araraquara School of Pharmaceutical Sciences, UNESP (PADC-FCF-Araraquara-UNESP) and the São Paulo State Research Aid Foundation (FAPESP) for financial support. EJ de Souza, MC da Rocha and MF Alberconi are Postgraduate students. We are also grateful to Ms VCO Alves, Ms TN Nunes and Mr MA Dangona for their technical assistance.

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Authors and Affiliations

  1. Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil

    Maria T. Pepato, Mayara F. Alberconi, Michelle C. da Rocha, Regina C. Vendramini & Iguatemy L. Brunetti

  2. Departamento de Química, Universidade Federal de São Carlos (UFSCar), Sao Carlos, SP, Brazil

    Alzir A. Batista

  3. Instituto de Química, Universidade de Brasília (UnB), Brasilia, DF, Brazil

    Elizeu J. de Souza & Edgardo Garcia

  4. Instituto de Química de São Carlos, Universidade de São Paulo, Sao Carlos, SP, Brazil

    Victor M. Deflon

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  1. Maria T. Pepato
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  2. Mayara F. Alberconi
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  3. Michelle C. da Rocha
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  4. Regina C. Vendramini
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Correspondence to Maria T. Pepato or Alzir A. Batista.

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Pepato, M.T., Alberconi, M.F., da Rocha, M.C. et al. Synthesis, characterization and biological analysis of the complex [VO(Hdhp)2] (H2dhp = 2,3-dihydroxypyridine). Transition Met Chem 33, 301–309 (2008). https://doi.org/10.1007/s11243-007-9003-5

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  • DOI: https://doi.org/10.1007/s11243-007-9003-5

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