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Synthesis, characterization and DNA binding studies of ruthenium(II) complexes: [Ru(bpy)2(dtmi)]2+ and [Ru(bpy)2(dtni)]2+

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Abstract

Two new ruthenium(II) polypyridyl complexes \({[\hbox{Ru(bpy)}_{2}\hbox{(dtmi)}](\hbox{ClO}_{4})_{2}}\) (1) (dtmi = 3-(pyrazin-2-yl)-as-triazino[5,6-f]-5-methoxylisatin) and \({[\hbox{Ru(bpy)}_{2}\hbox{(dtni)}](\hbox{ClO}_{4})_{2}}\) (2) (dtni = 3-(pyrazin-2-yl)-as-triazino[5,6-f]-5-nitroisatin) have been synthesized and characterized by elemental analysis, FAB-MS, ES-MS and 1H-n.m.r. The DNA-binding patterns of complexes were investigated by spectroscopic titration, viscosity measurements and thermal denaturation. The results indicate that the complexes (1) and (2) interact with calf thymus DNA (CT-DNA) by intercalative mode. Due to the withdrawing electronic substitutent in the intercalative ligand, ptni, the DNA-binding affinity of the complexes (2) is larger than that complex (1) does.

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Authors and Affiliations

  1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China

    Yun-Jun Liu, Xin Yu Wei, Wen-Jie Mei & Li-Xin He

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  1. Yun-Jun Liu
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  2. Xin Yu Wei
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  3. Wen-Jie Mei
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  4. Li-Xin He
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Correspondence to Yun-Jun Liu.

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Liu, YJ., Wei, X.Y., Mei, WJ. et al. Synthesis, characterization and DNA binding studies of ruthenium(II) complexes: [Ru(bpy)2(dtmi)]2+ and [Ru(bpy)2(dtni)]2+ . Transition Met Chem 32, 762–768 (2007). https://doi.org/10.1007/s11243-007-0246-y

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  • DOI: https://doi.org/10.1007/s11243-007-0246-y

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