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Spectral and biological investigation of 5-hydroxyl-3-oxopyrazoline 1-carbothiohydrazide and its transition metal complexes

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Abstract

Mononuclear complexes of 5-hydroxyl-3-oxopyrazoline-1-carbothiohydrazide, H3HOC, with VO2+, Co(II), Ni(II), Cu(II) and Cd(II) have been isolated. The elemental analyses, magnetic, spectral [u.v.–vis., i.r., e.s.r. 1H n.m.r. and mass] with thermal analysis have been used to characterize the isolated complexes. The ligand behaves as a mononegative tridentate with Ni(II) and Co(II) ions and neutral bidentate in [Cu(H3HOC)(NO3)2]0.5 H2O, [VO(H3HOC)SO4] and [Cd(H3HOC)Cl2C2H5OH]C2H5OH complexes. The octahedral structure was suggested for all the isolated complexes except VO2+. The TG analyses recorded different decomposition steps started at a temperature, indicating thermally unstable complexes. Screening showed antimicrobial activity for Cd(II) and Ni(II) complexes against the investigated bacteria as well as a significant adverse effects on DNA but a moderate effect is displayed with the other complexes.

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  1. Nashwa M. El-Metwaly

    Present address: Scientific Departments, Faculty of Education, Abha, Saudi Arabia

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  1. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

    Nashwa M. El-Metwaly

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  1. Nashwa M. El-Metwaly
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Correspondence to Nashwa M. El-Metwaly.

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El-Metwaly, N.M. Spectral and biological investigation of 5-hydroxyl-3-oxopyrazoline 1-carbothiohydrazide and its transition metal complexes. Transition Met Chem 32, 88–94 (2007). https://doi.org/10.1007/s11243-006-0135-9

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  • DOI: https://doi.org/10.1007/s11243-006-0135-9

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