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The photocleavage properties of a novel ruthenium(II) complex on liver cancer cells Bel-7402 DNA

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Abstract

A novel ruthenium(II) complex [Ru(bpy)2DMHPIP] (DMHPIP = 2-(3,5-dimethoxy-4-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline) (1) has been synthesized and characterized by elemental analysis, 1H-NMR and ESI-MS. The DNA binding properties of the complex has also been investigated by electronic spectra and emission spectra, and the results show that complex (1) bind to DNA with high affinity. On the other hand, the photocleavage property of complex (1) on liver cancer cells lines Bel-7402 DNA has been investigated by electrophoresis agarose gels, and the results show that the complex can promote liver cancer cells Bel-7402 DNA from the supercoiled form to the nicked form excellently.

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Authors and Affiliations

  1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P.R. China

    Wen-Jie Mei, Yun-Jun Liu, Na Wang & Yu-Zhuo Ma

  2. School of Life Science and Biopharmacology, Guangdong Pharmaceutical University, Guangzhou, 510006, P.R. China

    Hui Wang, Li-Qiong Luo & Shu-Lin Huang

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  1. Wen-Jie Mei
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  2. Yun-Jun Liu
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  3. Na Wang
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  4. Yu-Zhuo Ma
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  5. Hui Wang
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  7. Shu-Lin Huang
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Correspondence to Wen-Jie Mei.

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Mei, WJ., Liu, YJ., Wang, N. et al. The photocleavage properties of a novel ruthenium(II) complex on liver cancer cells Bel-7402 DNA. Transition Met Chem 31, 1024–1027 (2006). https://doi.org/10.1007/s11243-006-0104-3

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  • DOI: https://doi.org/10.1007/s11243-006-0104-3

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