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DNA Interactions of a Dinuclear Ruthenium(II) Complex Bridged by 1,3-bis(1,10-phenanthroline[5,6-d]imidazol-2-yl)benzene

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Abstract

A novel dinuclear ruthenium(II) complex [(phen)2Ru(mbpibH2)Ru(phen)2]4+ [phen = 1,10-phenanthroline; mbpibH2 = 1,3-bis(1,10-phenanthroline[5,6-d]imidazol-2-yl)-benzene] has been synthesized and characterized. The DNA-binding behavior of this complex has been studied by spectroscopic and viscosity measurements. Results suggest that the dinuclear ruthenium(II) complex intercalates into DNA base pairs via its bridging moiety. It has also been found that the dinuclear ruthenium(II) complex displays the enantiopreferential DNA-binding after equilibrium dialysis.

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References

  1. A. Sigel and H. Sigel, Metal Ions in Biological Systems, Marcel Dekker, New York, Vol. 33.

  2. M. Demeunynck C. Bailly W.D. Wilson (2003) DNA and RNA Binders: From Small Molecules to Drugs Weinheim Wiley-VCH

    Google Scholar 

  3. J.A. Cowan (2001) Curr. Opin. Chem. Biol. 5 634 Occurrence Handle10.1016/S1367-5931(01)00259-9 Occurrence Handle1:CAS:528:DC%2BD3MXovVCnsbw%3D

    Article  CAS  Google Scholar 

  4. K.E. Erkkila D.T. Odom J.K. Barton (1999) Chem. Rev. 99 2777 Occurrence Handle10.1021/cr9804341 Occurrence Handle1:CAS:528:DyaK1MXksl2ls7w%3D

    Article  CAS  Google Scholar 

  5. L.N. Ji X.H. Zou J.G. Liu (2001) Coord. Chem. Rev. 216–217 513 Occurrence Handle10.1016/S0010-8545(01)00338-1

    Article  Google Scholar 

  6. L.-N. Ji Q.-L. Zhang H. Chao (2001) Chinese Sci. Bull. 46 451 Occurrence Handle10.1007/BF03183383

    Article  Google Scholar 

  7. I. Ortmans C. Moucheron A. Kirsch-De Mesmaeker (1998) Coord. Chem. Rev. 168 233 Occurrence Handle10.1016/S0010-8545(97)00070-2 Occurrence Handle1:CAS:528:DyaK1cXhsFKrtrs%3D

    Article  CAS  Google Scholar 

  8. R.M. Hartshorn J.K. Barton (1992) J. Am. Chem. Soc. 114 5919 Occurrence Handle10.1021/ja00041a002 Occurrence Handle1:CAS:528:DyaK38Xmt12gu7g%3D

    Article  CAS  Google Scholar 

  9. R.B. Nair E.S. Teng S.L. Kirkland C.J. Murphy (1998) Inorg. Chem. 37 139 Occurrence Handle10.1021/ic970432j Occurrence Handle1:CAS:528:DyaK2sXotVCisr8%3D

    Article  CAS  Google Scholar 

  10. J.G. Collins A.D. Sleeman J.R. Aldrich-Wright I.D. Greguric T.W. Hambley (1998) Inorg. Chem. 37 3133 Occurrence Handle10.1021/ic971194v Occurrence Handle1:CAS:528:DyaK1cXjslWgsLY%3D

    Article  CAS  Google Scholar 

  11. E. Tuite P. Lincoln B. Nordén (1997) J. Am. Chem. Soc. 119 239 Occurrence Handle10.1021/ja961857s Occurrence Handle1:CAS:528:DyaK28XnsVemurg%3D

    Article  CAS  Google Scholar 

  12. A. Ambroise B.G. Maiya (2000) Inorg. Chem. 39 4256 Occurrence Handle10.1021/ic991468+ Occurrence Handle1:CAS:528:DC%2BD3cXlslKisbc%3D

    Article  CAS  Google Scholar 

  13. H. Chao, G. Yang, G.-Q. Xue, H. Li, H. Zhang, I.D. Williams, L.-N. Ji, X.-M. Chen and X.-Y. Li, J. Chem. Soc., Dalton Trans., 1326 (2001).

  14. H. Chao W.J. Mei Q.W. Huang L.N. Ji (2002) J. Inorg. Biochem. 92 165 Occurrence Handle10.1016/S0162-0134(02)00543-3 Occurrence Handle1:CAS:528:DC%2BD38XosFCntLY%3D

    Article  CAS  Google Scholar 

  15. C.-W. Jiang H. Chao H. Li J. L.-N. Ji (2003) Inorg. Biochem. 93 247 Occurrence Handle10.1016/S0162-0134(02)00577-9 Occurrence Handle1:CAS:528:DC%2BD3sXpsFOitg%3D%3D

    Article  CAS  Google Scholar 

  16. X.-L. Hong H. Chao L.-J. Lin K.-C. Zheng H. Li X.-L. Wang F.-C. Yun L.-N. Ji (2004) Helv. Chim. Acta. 87 1180 Occurrence Handle10.1002/hlca.200490108 Occurrence Handle1:CAS:528:DC%2BD2cXltlKks7c%3D

    Article  CAS  Google Scholar 

  17. L.-F. Tan H. Chao H. Li Y.-J. Liu B. Sun B. Wei L.-N. Ji (2005) J. Inorg. Biochem. 99 513 Occurrence Handle10.1016/j.jinorgbio.2004.10.028 Occurrence Handle1:CAS:528:DC%2BD2cXhtFGhsLnK

    Article  CAS  Google Scholar 

  18. Y.-J. Liu H. Chao L.-F. Tan Y.-X. Yuan W. Wei L.-N. Ji (2005) J. Inorg. Biochem. 99 530 Occurrence Handle10.1016/j.jinorgbio.2004.10.030 Occurrence Handle1:CAS:528:DC%2BD2cXhtFGhsLnE

    Article  CAS  Google Scholar 

  19. P. Lincoln and B. Norden, J. Chem. Soc., Chem. Comm., 2145 (1996).

  20. X.-H. Zou, B.-H. Ye, J.-G. Liu, Y. Xiong and L.-N. Ji, J. Chem. Soc., Dalton Trans., 1423 (1999).

  21. F.M. O’Reilly J.M. Kelly (2000) J. Phys. Chem. B. 104 7206 Occurrence Handle10.1021/jp000640o Occurrence Handle1:CAS:528:DC%2BD3cXkslWnuro%3D

    Article  CAS  Google Scholar 

  22. F.M. Foley, F.R. Keene and J.G. Collins, J. Chem. Soc., Dalton Trans., 2968 (2001).

  23. B. Önfelt P. Lincoln B. Nordén (2001) J. Am. Chem. Soc. 123 3630 Occurrence Handle10.1021/ja003624d Occurrence Handle1:CAS:528:DC%2BD3MXit1Crtr8%3D

    Article  CAS  Google Scholar 

  24. A. Brodkorb, A. Kirsch-De Mesmaeker, T.J. Rutherford and F.R. Keene, Eur. J. Inorg. Chem., 2151 (2001).

  25. J.A. Smith, J.G. Collins, B.T. Patterson and F.R. Keene, J. Chem. Soc., Dalton Trans., 1277 (2004).

  26. J. Aldrich-Wright, C. Brodie, E.C. Glazer, N.W. Luedtke, L. Elson-Schwab and Y. Tor, Chem. Commun., 1018 (2004).

  27. C.-W. Jiang H. Chao X.-L. Hong H. Li W.-J. Mei L.-N. Ji (2003) Inorg. Chem. Commun. 6 773 Occurrence Handle10.1016/S1387-7003(03)00109-6 Occurrence Handle1:CAS:528:DC%2BD3sXjtVymt74%3D

    Article  CAS  Google Scholar 

  28. J.-Z. Wu L. Yuan (2004) J. Inorg. Biochem. 98 41 Occurrence Handle10.1016/j.jinorgbio.2003.08.011 Occurrence Handle1:CAS:528:DC%2BD3sXpsVSqsbg%3D

    Article  CAS  Google Scholar 

  29. F.-R. Liu K.-Z. Wang G.-Y. Bai Y.-A. Zhang L.-H. Gao (2004) Inorg. Chem. 43 1799 Occurrence Handle10.1021/ic035109x Occurrence Handle1:CAS:528:DC%2BD2cXhtVylsbw%3D

    Article  CAS  Google Scholar 

  30. J. Marmur (1961) J. Mol. Biol. 3 208 Occurrence Handle1:CAS:528:DyaF3MXosl2kuw%3D%3D Occurrence Handle10.1016/S0022-2836(61)80047-8

    Article  CAS  Google Scholar 

  31. M.F. Reichmann S.A. Rice C.A. Thomas P. Doty (1954) J. Am. Chem. Soc. 76 3047 Occurrence Handle10.1021/ja01640a067 Occurrence Handle1:CAS:528:DyaG2cXmtVKmsg%3D%3D

    Article  CAS  Google Scholar 

  32. J.K. Barton J.J. Dannenberg A.L. Raphael (1984) J. Am. Chem. Soc. 106 2172 Occurrence Handle10.1021/ja00319a043 Occurrence Handle1:CAS:528:DyaL2cXhtlCntL0%3D

    Article  CAS  Google Scholar 

  33. B.P. Sullivan D.J. Salmon T.J. Meyer (1978) Inorg. Chem. 17 3334 Occurrence Handle10.1021/ic50190a006 Occurrence Handle1:CAS:528:DyaE1cXmtVyhtbw%3D

    Article  CAS  Google Scholar 

  34. H. Chao B.-H. Ye H. Li R.-H. Li J.-Y. Zhou Li.-N. Ji (2000) Polyhedron 19 1975 Occurrence Handle10.1016/S0277-5387(00)00500-3 Occurrence Handle1:CAS:528:DC%2BD3cXnvFSrurk%3D

    Article  CAS  Google Scholar 

  35. J.B. Chaires N. Dattagupta D.M. Crothers (1982) Biochemistry 21 3933 Occurrence Handle10.1021/bi00260a005 Occurrence Handle1:CAS:528:DyaL38Xks1Kjtbs%3D

    Article  CAS  Google Scholar 

  36. G. Cohen H. Eisenberg (1969) Biopolymers 8 45 Occurrence Handle10.1002/bip.1969.360080105 Occurrence Handle1:CAS:528:DyaF1MXltV2jtbY%3D

    Article  CAS  Google Scholar 

  37. G.M. Bryant J.E. Fergusson H.K.J. Powell (1971) Aust. J. Chem. 24 257 Occurrence Handle1:CAS:528:DyaE3MXpt12rsQ%3D%3D Occurrence Handle10.1071/CH9710257

    Article  CAS  Google Scholar 

  38. C. Hiort P. Lincoln B. Nordén (1993) J. Am. Chem. Soc. 115 3448 Occurrence Handle10.1021/ja00062a007 Occurrence Handle1:CAS:528:DyaK3sXksVCntLs%3D

    Article  CAS  Google Scholar 

  39. J.R. Lakowicz (1983) Principles of Fluorescence Spectroscopy Plenum Press New York

    Google Scholar 

  40. C.V. Kumar N.J. Turro J.K. Barton (1985) J. Am. Chem. Soc. 107 5518 Occurrence Handle10.1021/ja00305a032 Occurrence Handle1:CAS:528:DyaL2MXltF2hsLw%3D

    Article  CAS  Google Scholar 

  41. J.K. Barton J.M. Goldberg C.V. Kumar N.J. Turro (1986) J. Am. Chem. Soc. 108 2081 Occurrence Handle10.1021/ja00268a057 Occurrence Handle1:CAS:528:DyaL28XhsVGjs7w%3D

    Article  CAS  Google Scholar 

  42. S. Satyanarayana J.C. Dabroniak J.B. Chaires (1992) Biochemistry 31 9319 Occurrence Handle10.1021/bi00154a001 Occurrence Handle1:CAS:528:DyaK38Xls1Kjtbc%3D

    Article  CAS  Google Scholar 

  43. S. Satyanaryana J.C. Daborusak J.B. Chaires (1993) Biochemistry 32 2573 Occurrence Handle10.1021/bi00061a015

    Article  Google Scholar 

  44. J.K. Barton (1986) Science 233 727 Occurrence Handle1:CAS:528:DyaL28XlsVyqur0%3D

    CAS  Google Scholar 

  45. T.P. Shields J.K. Barton (1995) Biochemistry 34 15049 Occurrence Handle10.1021/bi00046a010 Occurrence Handle1:CAS:528:DyaK2MXovFOjurw%3D

    Article  CAS  Google Scholar 

  46. A. Sitlani C.M. Dupureur J.K. Barton (1993) J. Am. Chem. Soc. 115 12589 Occurrence Handle10.1021/ja00079a050 Occurrence Handle1:CAS:528:DyaK2cXntFOhuw%3D%3D

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, The Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat-Sen University, Guangzhou, 510275, China

    Hui Chao, Yi-Xian Yuan, Feng Zhou & Liang-Nian Ji

  2. The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510275, China

    Jian Zhang

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  1. Hui Chao
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  2. Yi-Xian Yuan
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  3. Feng Zhou
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  4. Liang-Nian Ji
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Correspondence to Hui Chao.

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Chao, H., Yuan, YX., Zhou, F. et al. DNA Interactions of a Dinuclear Ruthenium(II) Complex Bridged by 1,3-bis(1,10-phenanthroline[5,6-d]imidazol-2-yl)benzene. Transition Met Chem 31, 465–469 (2006). https://doi.org/10.1007/s11243-006-0013-5

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  • DOI: https://doi.org/10.1007/s11243-006-0013-5

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