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13C-n.m.r. studies of the binding of 1,3-diazinane-2-selenone and 1,3-diazipine-2-selenone to gold(I) drugs

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Abstract

The interaction of gold(I) thiomalate, Myocrisin [(Autm) n ] with 1,3-diazinane-2-selenone (DiazSe) and 1,3-diazipine-2-selenone (DiapSe) has been studied in aqueous solution using 13C-n.m.r. spectroscopy. It is observed that ternary complexes, (DiazSe–Au–tm and DiapSe–Au–tm, respectively) are formed on coordination of these ligands to (Autm) n . The 13C-n.m.r. data suggest that DiapSe binds more strongly to (Autm) n than does DiazSe, which binds more strongly compared to its analogous thione, 1,3-diazinane-2-thione (Diaz). A similar observation was made for the gold(I) thioglucose (Autg) reaction with DiazSe.

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Authors and Affiliations

  1. Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran, 31261, Saudi Arabia

    Anvarhusein A. Isab, Saeed Ahmad & Waqar Ashraf

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  1. Anvarhusein A. Isab
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  2. Saeed Ahmad
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  3. Waqar Ashraf
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Isab, A.A., Ahmad, S. & Ashraf, W. 13C-n.m.r. studies of the binding of 1,3-diazinane-2-selenone and 1,3-diazipine-2-selenone to gold(I) drugs. Transition Met Chem 30, 389–392 (2005). https://doi.org/10.1007/s11243-004-6966-3

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  • DOI: https://doi.org/10.1007/s11243-004-6966-3

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