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DNA-binding and photoactivated cleavage of enantiomeric ruthenium(II) complexes

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Abstract

A set of enantiomeric RuII complexes Δ- and Λ-[Ru(bpy)2TAPTP](PF6)2(bpy=2,2’-bipyridine, TAPTP=4,5,9,18-tetraazaphenanthreno[9,10-b]triphenylene) have been synthesized and characterized. Binding of both enantiomers to calf thymus DNA has been studied by spectroscopic methods, viscosity, and equilibrium dialysis. The experimental results indicated that both enantiomers bind to DNA by intercalation. Upon irradiation at 302 nm, both enantiomers were found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to a nicked form II, and obvious enantioselectively was observed on DNA cleavage, the Λ- enantiomer exhibiting higher cleaving efficiency. The mechanisms for DNA cleavage by the two enantiomers are also proposed.

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Authors and Affiliations

  1. Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen, 518060, PR China

    Qian-Ling Zhang, Jian-Hong Liu & Xiang-Zhong Ren

  2. School of Materials Science and Engineering, Xi’an University of Architecture and Technology, Xi’an, 710055, PR China

    Pei-Xin Zhang

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  1. Qian-Ling Zhang
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Zhang, QL., Liu, JH., Ren, XZ. et al. DNA-binding and photoactivated cleavage of enantiomeric ruthenium(II) complexes. Transition Met Chem 30, 285–289 (2005). https://doi.org/10.1007/s11243-004-4057-0

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