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Changes in thromboinflammatory profiles across the generations of transcatheter aortic heart valves

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Abstract

The transcatheter aortic valve replacement (TAVR) procedure was developed to provide patients with severe aortic stenosis an alternative to the surgical aortic valve replacement. Since the approval of the original SAPIEN the technology has rapidly evolved. While several approaches can be used for valve deployment, as delivery systems have become smaller and more flexible, the transfemoral approach has become the dominant technique for valve deployment. One hundred and forty five patients undergoing TAVR receiving one of four valve types (Sapien, Sapien XT, Sapien3 or CoreValve) via the femoral artery were included in this study. Platelet count, white blood cells count (WBC), Interleukin-6 (IL-6), and Serum Amyloid A (SAA) were determined before and after TAVR. Platelet counts declined after the procedure regardless of the valve type and were dependent upon the baseline platelet count. Use of conscious sedation blunted the decline in platelet count. With the newer generation valves, the rise in WBC post-TAVR was lower than observed with the Sapien, in keeping with less systemic inflammation. Consistent with WBC, IL-6 levels were lower following deployment of the newer generation valves. Elevations in plasma SAA, which occur following myocardial injury, were not reduced with the newer valves. Evolution of the TAVR technology has occurred rapidly over the last 5 years. The newer devices and smaller delivery systems are associated with less systemic inflammation, as reflected in WBC and plasma IL-6 levels. However, the acute phase reactant SAA remains unchanged, possibly reflecting different triggers for SAA following TAVR.

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Funding

TRS was supported in part by the Grant No. T32HL091812 from the Heart Lung and Blood Institute, National Institute of Health. MA was supported by the National Center for Advancing Translational Sciences UL1TR000117/UL1TR001998 and UK Healthcare. The content is solely the responsibility of the authors and does no necessarily represent the official views of the NIH.

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Authors and Affiliations

  1. Gill Heart and Vascular Institute, University of Kentucky, BBSRB B345, Lexington, KY, 40506, USA

    Travis Sexton, Maria Alkhasova & Susan Smyth

  2. Department of Physiology, University of Kentucky, Lexington, KY, USA

    Marcielle de Beer

  3. Lung and Vascular Institute, University of Cincinnati, Cincinnati, OH, USA

    Donald Lynch

Authors
  1. Travis Sexton
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  2. Maria Alkhasova
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  3. Marcielle de Beer
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  4. Donald Lynch
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  5. Susan Smyth
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Corresponding author

Correspondence to Susan Smyth.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sexton, T., Alkhasova, M., de Beer, M. et al. Changes in thromboinflammatory profiles across the generations of transcatheter aortic heart valves. J Thromb Thrombolysis 47, 174–178 (2019). https://doi.org/10.1007/s11239-018-1782-3

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  • DOI: https://doi.org/10.1007/s11239-018-1782-3

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