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Assessing in vivo platelet activation in patients with liver diseases

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References

  1. Egan K, Dillon A, Dunne E, Kevane B, Galvin Z, Maguire P, et al. (2016) Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation. J Thromb Thrombolysis, in press

  2. Davi G, Ferro D, Basili S, Iuliano L, Camastra C, Giammarresi C et al (1998) Increased thromboxane metabolites excretion in liver cirrhosis. Thromb Haemost 79(4):747–751

    CAS  PubMed  Google Scholar 

  3. Basili S, Raparelli V, Riggio O, Merli M, Carnevale R, Angelico F et al (2011) NADPH oxidase-mediated platelet isoprostane over-production in cirrhotic patients: implication for platelet activation. Liver Int 31(10):1533–1540

    Article  CAS  PubMed  Google Scholar 

  4. Panasiuk A, Prokopowicz D, Zak J, Matowicka-Karna J, Osada J, Wysocka J (2001) Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4. Hepatogastroenterology 48(39):818–822

    CAS  PubMed  Google Scholar 

  5. Sayed D, Amin NF, Galal GM (2010) Monocyte-platelet aggregates and platelet micro-particles in patients with post-hepatitic liver cirrhosis. Thromb Res 125(5):e228–e233

    Article  CAS  PubMed  Google Scholar 

  6. Lisman T, Porte RJ (2012) Pitfalls in assessing platelet activation status in patients with liver disease. Liver Int 32(6):1027

    Article  PubMed  Google Scholar 

  7. Vukovich T, Teufelsbauer H, Fritzer M, Kreuzer S, Knoflach P (1995) Hemostasis activation in patients with liver cirrhosis. Thromb Res 77(3):271–278

    Article  CAS  PubMed  Google Scholar 

  8. Northup PG, Sundaram V, Fallon MB, Reddy KR, Balogun RA, Sanyal AJ et al (2008) Hypercoagulation and thrombophilia in liver disease. J Thromb Haemost 6(1):2–9

    CAS  PubMed  Google Scholar 

  9. Alkozai EM, Porte RJ, Adelmeijer J, Zanetto A, Simioni P, Senzolo M et al (2015) No evidence for increased platelet activation in patients with hepatitis B- or C-related cirrhosis and hepatocellular carcinoma. Thromb Res 135(2):292–297

    Article  CAS  PubMed  Google Scholar 

  10. Potze W, Siddiqui MS, Boyett SL, Adelmeijer J, Daita K, Sanyal AJ, et al. (2016) Preserved hemostatic status in patients with non-alcoholic fatty liver disease. J Hepatol, in press

  11. Laffi G, Cinotti S, Filimberti E, Ciabattoni G, Caporale R, Marra F et al (1996) Defective aggregation in cirrhosis is independent of in vivo platelet activation. J Hepatol 24(4):436–443

    Article  CAS  PubMed  Google Scholar 

  12. Lisman T, Adelmeijer J, de Groot PG, Janssen HL, Leebeek FW (2006) No evidence for an intrinsic platelet defect in patients with liver cirrhosis–studies under flow conditions. J Thromb Haemost 4(9):2070–2072

    Article  CAS  PubMed  Google Scholar 

  13. Lisman T, Bongers TN, Adelmeijer J, Janssen HL, de Maat MP, de Groot PG et al (2006) Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology 44(1):53–61

    Article  CAS  PubMed  Google Scholar 

  14. Hugenholtz GC, Adelmeijer J, Meijers JC, Porte RJ, Stravitz RT, Lisman T (2013) An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: implications for hemostasis and clinical outcome. Hepatology 58(2):752–761

    Article  CAS  PubMed  Google Scholar 

  15. Weeder PD, Porte RJ, Lisman T (2014) Hemostasis in liver disease: implications of new concepts for perioperative management. Transfus Med Rev 28(3):107–113

    Article  PubMed  Google Scholar 

  16. Potze W, Porte RJ, Lisman T (2014) Management of coagulation abnormalities in liver disease. Expert Rev Gastroenterol Hepatol 26:1–12

    Google Scholar 

  17. Northup PG, Caldwell SH (2013) Coagulation in liver disease: a guide for the clinician. Clin Gastroenterol Hepatol 11(9):1064–1074

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Surgical Research Laboratory and Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, BA33, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands

    Ton Lisman

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  1. Ton Lisman
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Correspondence to Ton Lisman.

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Lisman, T. Assessing in vivo platelet activation in patients with liver diseases. J Thromb Thrombolysis 43, 52–53 (2017). https://doi.org/10.1007/s11239-016-1405-9

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  • DOI: https://doi.org/10.1007/s11239-016-1405-9

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