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Association between sleep condition and arterial stiffness in Chinese adult with nonalcoholic fatty liver disease

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Abstract

Nonalcoholic fatty liver (NAFLD) usually has worse cardiovascular risk factors. Given the potential association between deterioration of sleep and arterial stiffness, we aim to investigate the association between deterioration of sleep and arterial stiffness in a middle-aged Chinese population with NAFLD. In this cross-sectional study, 15,372 Chinese aged 40–60 years who participated in periodic health checkups in central south China, were included. Self-reported sleep duration and sleep quality, anthropometric, biochemical, and liver ultrasound scan were analyzed and brachial-ankle pulse wave velocity (baPWV) was used as the indicator of arterial stiffness. Poor sleep quality was found to be associated with increased arterial stiffness, with odds ratios and 95 % confidence intervals (CIs) of 2.28 (95 % CI, 1.53–3.38) compared with good sleep quality. Using sleep duration ≥ 8 h as the reference, there was no significant association between sleep duration of ≤ 6 or 6–8 h and arterial stiffness after multivariable-adjusted. In additional analyses, further investigation of the association of different combinations of sleep duration and quality in relation to arterial stiffness indicated participants with poor sleep quality and sleep duration ≤ 6 h were more likely to have arterial stiffness than those with good quality sleep who sleep for ≥ 8 h (OR 2.59, 95 % CI 1.58–4.24). The present study indicates that short sleep duration, poor sleep quality in individuals with NAFLD correlate with increased arterial stiffness.

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Acknowledgments

We thank Chang Liu, for his help in programming and statistical analyses as well as all participants for their contribution. This work was supported in part by a grant from Key Science and Technology Projects in Hunan Province (2014SK3062) and a grant from Science and Technology Plan Projects (2013BAI04B00).

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Authors and Affiliations

  1. Health Management Center, The Third Xiangya Hospital, Central South University, Tongzipo Road 138, Changsha, 410013, Hunan Province, China

    Xia Cao & Zhiheng Chen

  2. Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China

    Jiansong Zhou

  3. Clinical Pharmacology Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China

    Hong Yuan

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  1. Xia Cao
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Correspondence to Zhiheng Chen.

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Cao, X., Zhou, J., Yuan, H. et al. Association between sleep condition and arterial stiffness in Chinese adult with nonalcoholic fatty liver disease. J Thromb Thrombolysis 42, 127–134 (2016). https://doi.org/10.1007/s11239-016-1356-1

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