Skip to main content

Advertisement

SpringerLink
Log in

Epidemiological association between migraine and lipoprotein(a): a systematic review

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

Abstract

Migraine is a relatively frequent and disabling condition, which poses a large clinical and economical burden on human society. Since there is now emerging evidence that the risk of cardiovascular diseases may be significantly increased in patients with migraine, and that lipoprotein(a) is a powerful, independent cardiovascular risk factor, we performed an electronic searched on Medline, Scopus and Web of Science using the keywords “migraine” and “lipoprotein(a)” or “apolipoprotein(a)” or “Lp(a)” or “apo(a)”, with no language or date restriction. The electronic search produced four cross-sectional studies which reported original data about the epidemiological association between lipoprotein(a) and migraine, and used standardized criteria for diagnosing migraine. In only one out of the four studies the concentration of lipoprotein(a) was found to be higher in migraineurs than in controls, whereas in the remaining three investigations lipoprotein(a) levels were found to be virtually identical between cases and controls. This analysis suggests that if any epidemiological and clinical link exists between migraine and cardiovascular disease, a direct involvement of lipoprotein(a) seems unlikely according to the available epidemiological evidence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bigal ME, Lipton RB (2009) The epidemiology, burden, and comorbidities of migraine. Neurol Clin 27:321–334

    Article  PubMed  Google Scholar 

  2. Steiner TJ, Stovner LJ, Birbeck GL (2013) Migraine: the seventh disabler. Headache 53:227–229

    Article  PubMed  Google Scholar 

  3. Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808

    Article  Google Scholar 

  4. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 339:b3914

    Article  PubMed Central  PubMed  Google Scholar 

  5. Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291

    Article  CAS  PubMed  Google Scholar 

  6. Kurth T, Gaziano JM, Cook NR, Bubes V, Logroscino G, Diener HC, Buring JE (2007) Migraine and risk of cardiovascular disease in men. Arch Intern Med 167:795–801

    Article  PubMed  Google Scholar 

  7. Nordestgaard BG, Chapman MJ, Ray K, Borén J, Andreotti F, Watts GF, Ginsberg H, Amarenco P, Catapano A, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Reiner Z, Taskinen MR, Tokgözoglu L, Tybjærg-Hansen A, European Atherosclerosis Society Consensus Panel (2010) Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J 31:2844–2853

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Lippi G, Franchini M, Targher G (2011) Screening and therapeutic management of lipoprotein(a) excess: review of the epidemiological evidence, guidelines and recommendations. Clin Chim Acta 412:797–801

    Article  CAS  PubMed  Google Scholar 

  9. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, Creager MA, Culebras A, Eckel RH, Hart RG, Hinchey JA, Howard VJ, Jauch EC, Levine SR, Meschia JF, Moore WS, Nixon JV, Pearson TA, American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Epidemiology and Prevention; Council for High Blood Pressure Research; Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research (2011) Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42:517–584

    Article  PubMed  Google Scholar 

  10. Lippi G, Guidi G (1999) Biochemical risk factors and patient’s outcome: the case of lipoprotein(a). Clin Chim Acta 280:59–71

    Article  CAS  PubMed  Google Scholar 

  11. Malaguarnera M, Vacante M, Russo C et al (2013) Lipoprotein(a) in cardiovascular diseases. Biomed Res Int 2013:650989

    PubMed Central  PubMed  Google Scholar 

  12. Becker RC, Smyth S (2012) Biomarker science: on a theme of personalized medicine. J Thromb Thrombolysis 34:141–142

    Article  PubMed  Google Scholar 

  13. Lippi G, Favalor EJ, Simundic AM (2012) Biomedical research platforms and their influence on article submissions and journal rankings: an update. Biochem Med (Zagreb) 22:7–14

    Article  Google Scholar 

  14. Kurth T, Ridker PM, Buring JE (2008) Migraine and biomarkers of cardiovascular disease in women. Cephalalgia 28:49–56

    CAS  PubMed  Google Scholar 

  15. Cinzia F, Daniela P, Elena S, Francesco S, Emilia A, Sandra F, Graziano A, Domenico P, Rosanna A (2009) Lipoprotein(a) [Lp(a)]: a possible link between migraine and stroke. Transl Res 153:44–47

    Article  CAS  PubMed  Google Scholar 

  16. Gruber HJ, Bernecker C, Pailer S, Lechner A, Horejsi R, Möller R, Fazekas F, Truschnig-Wilders M (2010) Lipid profile in normal weight migraineurs — evidence for cardiovascular risk. Eur J Neurol 17:419–425

    Article  PubMed  Google Scholar 

  17. Teber S, Bektas Ö, Yılmaz A, Aksoy E, Akar N, Deda G (2011) Lipoprotein a levels in pediatric migraine. Pediatr Neurol 45:225–228

    Article  PubMed  Google Scholar 

  18. Berthold HK, Gouni-Berthold I (2013) Hyperlipoproteinemia(a): clinical significance and treatment options. Atheroscler Suppl 14:1–5

    Article  CAS  PubMed  Google Scholar 

  19. Lippi G, Guidi G (2003) Lipoprotein(a): an emerging cardiovascular risk factor. Crit Rev Clin Lab Sci 40:1–42

    Article  CAS  PubMed  Google Scholar 

  20. Eising E, Datson AN, van den Maagdenberg AM, Ferrari MD (2013) Epigenetic mechanisms in migraine: a promising avenue. BMC Med 11:26

    Article  PubMed Central  PubMed  Google Scholar 

  21. Hoover-Plow J, Hart E, Gong Y, Shchurin A, Schneeman T (2009) A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response. Exp Biol Med (Maywood) 234:28–34

    Article  CAS  Google Scholar 

  22. Lippi G, Targher G, Franchini M, Guidi GC (2009) Biochemical correlates of lipoprotein(a) in a general adult population. Possible implications for cardiovascular risk assessment. J Thromb Thrombolysis 27:44–47

    Article  CAS  PubMed  Google Scholar 

  23. Goadsby PJ (2007) Cortical spreading depression—better understanding and more questions. Focus on “distinct vascular conduction with cortical spreading depression”. J Neurophysiol 97:3827

    Article  PubMed  Google Scholar 

  24. Schachinger V, Halle M, Minners J, Berg A, Zeiher AM (1997) Lipoprotein(a) selectively impairs receptor-mediated endothelial vasodilator function of the human coronary circulation. J Am Coll Cardiol 30:927–934

    Article  CAS  PubMed  Google Scholar 

  25. Bigal ME, Lipton RB (2008) Putative mechanisms of the relationship between obesity and migraine progression. Curr Pain Headache Rep 12:207–212

    Article  PubMed  Google Scholar 

  26. Spence JD, Koschinsky M (2012) Mechanisms of lipoprotein(a) pathogenicity: prothrombotic, proatherosclerotic, or both? Arterioscler Thromb Vasc Biol 32:1550–1551

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service of Clinical Governance, General Hospital of Trento, Trento, Italy

    Camilla Mattiuzzi

  2. Emergency Department, Academic Hospital of Parma, Parma, Italy

    Gianfranco Cervellin

  3. Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy

    Giuseppe Lippi

  4. U.O. Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci, 14, 43126, Parma, Italy

    Giuseppe Lippi

Authors
  1. Camilla Mattiuzzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gianfranco Cervellin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giuseppe Lippi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Giuseppe Lippi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mattiuzzi, C., Cervellin, G. & Lippi, G. Epidemiological association between migraine and lipoprotein(a): a systematic review. J Thromb Thrombolysis 39, 113–117 (2015). https://doi.org/10.1007/s11239-014-1079-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-014-1079-0

Keywords

Search

Navigation