Skip to main content
SpringerLink
Log in

Novel mediators and biomarkers of thrombosis

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

Abstract

Spurred by advances in understanding the molecular basis of thrombosis, this issue of the Journal of Thrombosis and Thrombolysis is devoted to exploring aspects of novel paradigms and their potential impact on diagnosis and treatment. Complex interplay between blood and vascular cells, inflammation, and pro- and anti-coagulant pathways determines the formation and stability of arterial and venous thrombosis. A causal role for inflammation in coronary artery disease is currently being tested in large clinical trials. Basic science observations implicate inflammation in venous thromboembolic disorders and inflammatory processes, may have a similar influence on device thrombosis. In this article and throughout this issue of the Journal, we discuss biomarkers and mediators associated with arterial and venous thrombosis, atrial fibrillation, and other clinical scenarios.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Coller BS (2005) Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene? Arterioscler Thromb Vasc Biol 25:658–670

    Article  CAS  PubMed  Google Scholar 

  2. de Boer OJ, Li X, Teeling P et al (2013) Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction. Thromb Haemost 109:290–297

    Article  PubMed  Google Scholar 

  3. Bahou WF (2012) Platelet systems biology using integrated genetic and proteomic platforms. Thromb Res 129(Suppl 1):S38–S45

    Article  CAS  PubMed  Google Scholar 

  4. Wisler JW, Becker RC (2013) Emerging paradigms in arterial thrombosis. J Thromb Thrombolysis 15(12):2329–2337

    Google Scholar 

  5. Clancy L, Freedman JE (2013) New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer. J Thromb Thrombolysis. doi:10.1007/s11239-013-1001-1

  6. Smyth SS, McEver RP, Weyrich AS et al (2009) Platelet functions beyond hemostasis. J Thromb Haemost 7:1759–1766

    Article  CAS  PubMed  Google Scholar 

  7. Modjeski KL, Morrell CN (2013) Small cells, big effects: the role of platelets in transplant vasculopathy. J Thromb Thrombolysis. doi:10.1007/s11239-013-0999-4

  8. Borissoff JI, Joosen IA, Versteylen MO, Spronk HM, ten Cate H, Hofstra L (2012) Accelerated in vivo thrombin formation independently predicts the presence and severity of CT angiographic coronary atherosclerosis. JACC Cardiovasc Imaging 5:1201–1210

    Article  PubMed  Google Scholar 

  9. Brummel-Ziedins KE, Everse SJ, Mann KG, Orfeo T (2013) Modeling thrombin generation: plasma composition based approach. J Thromb Thrombolysis. doi:10.1007/s11239-013-1006-9

  10. Kalz J, Ten Cate H, Spronk HM (2013) Thrombin generation and atherosclerosis. J Thromb Thrombolysis. doi:10.1007/s11239-013-1026-5

  11. Steinhubl SR, Eikelboom JW, Hylek EM, Dauerman HL, Smyth SS, Becker RC (2013) Antiplatelet therapy in prevention of cardio- and venous thromboembolic events. J Thromb Thrombolysis. doi:10.1007/s11239-013-1023-8

  12. Bain J, Oyler DR, Smyth SS, Macaulay TE (2013) Pathophysiology and pharmacologic treatment of venous thromboembolism. Curr Drug Targets [Epub ahead of print]

  13. Brill A, Fuchs TA, Chauhan AK et al (2011) Von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood 117:1400–1407

    Article  CAS  PubMed  Google Scholar 

  14. Fuchs TA, Brill A, Wagner DD (2012) Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol 32:1777–1783

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Glynn RJ, Danielson E, Fonseca FA et al (2009) A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med 360:1851–1861

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Patterson KA, Zhang X, Wrobleski SK et al (2013) Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects. Thromb Res 131:268–276

    Article  CAS  PubMed  Google Scholar 

  17. Meijer WG, Croes LM, Jenni B, Lehmicke LG, Lidstrom ME, Dijkhuizen L (1990) Characterization of Xanthobacter strains H4-14 and 25a and enzyme profiles after growth under autotrophic and heterotrophic conditions. Arch Microbiol 153:360–367

    Article  CAS  PubMed  Google Scholar 

  18. Yin T, Miyata T (2013) Dysfunction of protein C anticoagulant system, main genetic risk factor for venous thromboembolism in Northeast Asians. J Thromb Thrombolysis. doi:10.1007/s11239-013-1005-x

  19. Lim HS, Willoughby SR, Schultz C et al (2013) Effect of atrial fibrillation on atrial thrombogenesis in humans: impact of rate and rhythm. J Am Coll Cardiol 61:852–860

    Article  PubMed  Google Scholar 

  20. Kornej J, Apostolakis S, Bollmann A, Lip GY (2013) The emerging role of biomarkers in atrial fibrillation. Can J Cardiol 29:1181–1193

    Article  PubMed  Google Scholar 

  21. Hijazi Z, Siegbahn A, Andersson U et al (2013) High sensitivity troponin I for risk assessment in patients with atrial fibrillation: insights from the ARISTOTLE trial. Circulation. doi:10.1161/CIRCULATIONAHA.113.006286

  22. Rodes-Cabau J, Dauerman HL, Cohen MG et al (2013) Antithrombotic treatment in transcatheter aortic valve implantation: insights for cerebrovascular and bleeding events. J Am Coll Cardiol 62(25):2349–2359

    Google Scholar 

  23. Rowley JW, Finn AV, French PA et al (2012) Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. Circ Cardiovasc Interv 5:296–304

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank Susan Quick for excellent editorial assistance. This work was supported in part by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR000117 and TL1TR000115. TS was supported in part by T32HL091812 from the Heart Lung and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This material is also based on work supported in part by resources at the Lexington VA Medical Center.

Author information

Authors and Affiliations

  1. Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, 255 BBRSB, 741 S. Limestone Street, Lexington, KY, 40536-0200, USA

    Travis Sexton & Susan S. Smyth

  2. Lexington VA Medical Center, Lexington, USA

    Susan S. Smyth

Authors
  1. Travis Sexton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susan S. Smyth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susan S. Smyth.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sexton, T., Smyth, S.S. Novel mediators and biomarkers of thrombosis. J Thromb Thrombolysis 37, 1–3 (2014). https://doi.org/10.1007/s11239-013-1034-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-013-1034-5

Keywords

Search

Navigation