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Rivaroxaban for the treatment of consumptive coagulopathy associated with a vascular malformation

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Abstract

The localized activation of coagulation in vascular malformations can lead to a consumptive coagulopathy characterized by elevated D-dimers and a consumption of fibrinogen and platelets, eventually giving rise to a bleeding tendency. By reducing coagulation activation, anticoagulant treatment with heparin is able to limit this haemostatic dysregulation and the associated bleeding diathesis. Here, we present a case of a consumptive coagulopathy due to a large venous malformation with a sustained correction of the fibrinogen depletion and associated bleeding tendency both with subcutaneous enoxaparin and with the oral factor Xa inhibitor rivaroxaban.

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Authors and Affiliations

  1. Vascular Medicine and Haemostasis, Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, Bus 911, 3000, Leuven, Belgium

    Christophe Vandenbriele, Thomas Vanassche, Marijke Peetermans, Peter Verhamme & Kathelijne Peerlinck

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  1. Christophe Vandenbriele
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  2. Thomas Vanassche
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  3. Marijke Peetermans
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  4. Peter Verhamme
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  5. Kathelijne Peerlinck
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Correspondence to Christophe Vandenbriele.

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Vandenbriele, C., Vanassche, T., Peetermans, M. et al. Rivaroxaban for the treatment of consumptive coagulopathy associated with a vascular malformation. J Thromb Thrombolysis 38, 121–123 (2014). https://doi.org/10.1007/s11239-013-1024-7

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  • DOI: https://doi.org/10.1007/s11239-013-1024-7

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