Journal of Thrombosis and Thrombolysis

, Volume 37, Issue 2, pp 234–241 | Cite as

Structure–function relationships of factor Xa inhibitors: implications for the practicing clinician

  • Benjamin A. Steinberg
  • Richard C. Becker


The recent development and approval of novel oral anticoagulants represents a significant success in the intelligent design of target-specific therapeutics. However, while these agents obviate many of the shortcomings of their predecessor (warfarin), they present novel challenges in pharmacologic management as well. Each was designed to have high oral bioavailability and high affinity for its target molecule, conveying significant anticoagulant effects. Yet, such unique drug–ligand binding, coupled with unfamiliar drug interactions and renal-based clearance, represent challenges to clinical management. The current review describes the development and pharmacokinetic properties of these agents, in the context of their clinical utility and pitfalls.


Factor Xa inhibitor Structure Function Review 



Dr. Steinberg was funded by NIH T-32 training Grant #5 T32 HL 7101-37. The authors wish to acknowledge Ms. Seanna Horar for her graphic design input.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Duke University Medical CenterDurhamUSA
  2. 2.Duke Clinical Research InstituteDurhamUSA

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