Journal of Thrombosis and Thrombolysis

, Volume 36, Issue 4, pp 475–483 | Cite as

The Swiss cohort of elderly patients with venous thromboembolism (SWITCO65+): rationale and methodology

  • Marie MéanEmail author
  • Marc Righini
  • Kurt Jaeger
  • Hans-Jürg Beer
  • Beat Frauchiger
  • Joseph Osterwalder
  • Nils Kucher
  • Bernhard Lämmle
  • Jacques Cornuz
  • Anne Angelillo-Scherrer
  • Nicolas Rodondi
  • Andreas Limacher
  • Sven Trelle
  • Christian M. Matter
  • Marc Husmann
  • Martin Banyai
  • Markus Aschwanden
  • Michael Egloff
  • Lucia Mazzolai
  • Olivier Hugli
  • Henri Bounameaux
  • Drahomir Aujesky


Venous thromboembolism (VTE) is common and has a high impact on morbidity, mortality, and costs of care. Although most of the patients with VTE are aged ≥65 years, there is little data about the medical outcomes in the elderly with VTE. The Swiss Cohort of Elderly Patients with VTE (SWITCO65+) is a prospective multicenter cohort study of in- and outpatients aged ≥65 years with acute VTE from all five Swiss university and four high-volume non-university hospitals. The goal is to examine which clinical and biological factors and processes of care drive short- and long-term medical outcomes, health-related quality of life, and medical resource utilization in elderly patients with acute VTE. The cohort also includes a large biobank with biological material from each participant. From September 2009 to March 2012, 1,863 elderly patients with VTE were screened and 1003 (53.8 %) were enrolled in the cohort. Overall, 51.7 % of patients were aged ≥75 years and 52.7 % were men. By October 16, 2012, after an average follow-up time of 512 days, 799 (79.7 %) patients were still actively participating. SWITCO65+ is a unique opportunity to study short- and long-term outcomes in elderly patients with VTE. The Steering Committee encourages national and international collaborative research projects related to SWITCO65+, including sharing anonymized data and biological samples.


Cohort study Venous thromboembolism Elderly patients Biobank 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Marie Méan
    • 1
    Email author
  • Marc Righini
    • 2
  • Kurt Jaeger
    • 3
  • Hans-Jürg Beer
    • 4
  • Beat Frauchiger
    • 5
  • Joseph Osterwalder
    • 6
  • Nils Kucher
    • 7
  • Bernhard Lämmle
    • 8
  • Jacques Cornuz
    • 9
  • Anne Angelillo-Scherrer
    • 10
  • Nicolas Rodondi
    • 1
  • Andreas Limacher
    • 11
  • Sven Trelle
    • 11
  • Christian M. Matter
    • 12
  • Marc Husmann
    • 13
  • Martin Banyai
    • 14
  • Markus Aschwanden
    • 3
  • Michael Egloff
    • 4
  • Lucia Mazzolai
    • 15
  • Olivier Hugli
    • 16
  • Henri Bounameaux
    • 2
  • Drahomir Aujesky
    • 1
  1. 1.Division of General Internal MedicineBern University HospitalBernSwitzerland
  2. 2.Division of Angiology and HemostasisGeneva University HospitalGenevaSwitzerland
  3. 3.Department of AngiologyBasel University HospitalBaselSwitzerland
  4. 4.Department of Internal MedicineCantonal Hospital of BadenBadenSwitzerland
  5. 5.Department of Internal MedicineCantonal Hospital of FrauenfeldFrauenfeldSwitzerland
  6. 6.Emergency DepartmentCantonal Hospital of St. GallenSt. GallenSwitzerland
  7. 7.Division of AngiologyBern University HospitalBernSwitzerland
  8. 8.Division of Hematology and Central Hematology LaboratoryBern University HospitalBernSwitzerland
  9. 9.Department of Ambulatory Care and Community MedicinePoliclinique Médicale UniversitaireLausanneSwitzerland
  10. 10.Service and Central Laboratory of HematologyLausanne University HospitalLausanneSwitzerland
  11. 11.Clinical Trials UnitUniversity of BernBernSwitzerland
  12. 12.Cardiovascular Research, Institute of Physiology, Zurich Center for Integrative Human PhysiologyUniversity of ZurichZurichSwitzerland
  13. 13.Division of AngiologyZurich University HospitalZurichSwitzerland
  14. 14.Division of AngiologyCantonal Hospital of LucerneLucerneSwitzerland
  15. 15.Service of AngiologyLausanne University HospitalLausanneSwitzerland
  16. 16.Emergency DepartmentLausanne University HospitalLausanneSwitzerland

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