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The Factor V Leiden mutation is associated with a higher blood haemoglobin concentration in women below 50 of the Malmö Thrombophilia Study (MATS)

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Abstract

The aim of this study was to investigate a relationship between FVL-mutation and levels of haemoglobin (Hb) in patients with venous thromboembolism (VTE). From March 1998 to December 2005, 927 consecutive patients with objectively diagnosed VTE were registered in the Malmö Thrombophilia Study (MATS). Female patients with FVL-mutation below 50 years of age had significantly higher median-Hb (133 vs. 126 g/l; P < 0.001) compared to female patients below the age of 50 years without FVL. No significant difference could be found for men or women above 50 years of age or men below 50 years of age. Female patients below the age of 50 years with FVL-mutation and VTE are associated with higher median Hb, and this finding is in accordance with earlier hypothesis that FVL-mutation may have constituted an evolutionary selection advantage.

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Acknowledgements

We are most grateful to Andreas Hillarp for reading our project and sharing his scientific expertise (experience). We also thank Camilla Nilsson for skilful technical assistance. The MATS study is in part supported by Anna o Edwin Bergers’ foundation, Stockholm.

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Authors and Affiliations

  1. Malmö Centre for Thrombosis and Haemostasis, 20502, Malmö, Sweden

    Nazim Isma, Thomas Breslin, Bengt Lindblad & Peter J. Svensson

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  1. Nazim Isma
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  2. Thomas Breslin
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  3. Bengt Lindblad
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  4. Peter J. Svensson
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Correspondence to Nazim Isma.

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Isma, N., Breslin, T., Lindblad, B. et al. The Factor V Leiden mutation is associated with a higher blood haemoglobin concentration in women below 50 of the Malmö Thrombophilia Study (MATS). J Thromb Thrombolysis 28, 255–258 (2009). https://doi.org/10.1007/s11239-008-0293-z

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  • DOI: https://doi.org/10.1007/s11239-008-0293-z

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