Abstract
Patients suffering from Philadelphia chromosome-negative chronic myeloproliferative disease (Ph− CMPD), such as polycythaemia vera (PV), are frequently JAK2V617F-mutated and have an elevated risk for thromboembolic complications. Recent data indicated that the molecular basis of JAK2V617F and thrombosis might be related to increased expression of CD239, the Lutheran blood group/basal cell adhesion molecule, in PV-derived red blood cells. The aim of this study was to clarify whether JAK2V617F PV with thromboembolism is characterised by CD239 overexpression. Leukocyte-derived JAK2V617F was detectable in bone marrow cells but also in liver and spleen explants and transplants after thrombosis (95% JAK2V617F-positive Ph− CMPD, n = 66). CD239 was expressed in a constitutive fashion in PV-derived bone marrow cells and thus a pro-thrombotic function does not seem to be mediated by increased CD239 expression alone.
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Acknowledgments
The authors wish to thank Ms. Sabine Schröter and Ms. Anna-Lena Becker for their skilful work in the laboratory. Research grants: Deutsche Krebshilfe, Dr. Mildred Scheel Stiftung 10-2191 (O.B., H.K.), Deutsche Forschungsgemeinschaft–DFG BO 1954/1-1 (O.B., H.K.), Hochschul-interne Leistungsförderung–HiLF 11/07, Medizinische Hochschule Hannover (K.H.).
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Hussein, K., Theophile, K., Denzer, K. et al. Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases. J Thromb Thrombolysis 28, 299–303 (2009). https://doi.org/10.1007/s11239-008-0285-z
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DOI: https://doi.org/10.1007/s11239-008-0285-z