Skip to main content
Log in

Platelet biology for the clinician-scientist: an evolution of understanding

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Kleiman NS et al (2008) Platelets: developmental biology, physiology and translatable platfors for preclinical investigation and drug development. Platelets (in press)

  2. Clarke MC et al (2003) Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. J Cell Biol 160(4):577–587

    Article  PubMed  CAS  Google Scholar 

  3. Kaluzhny Y, Ravid K (2004) Role of apoptotic processes in platelet biogenesis. Acta Haematol 111(1–2):67–77

    Article  PubMed  Google Scholar 

  4. Shim MH et al (2004) Gene expression profile of primary human CD34+CD38lo cells differentiating along the megakaryocyte lineage. Exp Hematol 32(7):638–648

    Article  PubMed  CAS  Google Scholar 

  5. Macaulay IC et al (2007) Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood 109(8):3260–3269

    Article  PubMed  CAS  Google Scholar 

  6. McRedmond JP et al (2004) Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics 3(2):133–144

    PubMed  CAS  Google Scholar 

  7. Buckwalter JA, Blythe WB, Brinkhous KM (1949) Effect of blood platelets on prothrombin utilization of dog and human plasmas. Am J Physiol 159(2):316–321

    PubMed  CAS  Google Scholar 

  8. Bouchard BA et al (1997) Effector cell protease receptor-1, a platelet activation-dependent membrane protein, regulates prothrombinase-catalyzed thrombin generation. J Biol Chem 272(14):9244–9251

    Article  PubMed  CAS  Google Scholar 

  9. Brummel KE et al (2001) Oral anticoagulation thresholds. Circulation 104(19):2311–2317

    Article  PubMed  CAS  Google Scholar 

  10. Monroe DM, Hoffman M, Roberts HR (2002) Platelets and thrombin generation. Arterioscler Thromb Vasc Biol 22:1381–1389

    Article  PubMed  CAS  Google Scholar 

  11. Munnix ICA et al (2007) Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Arterioscler Thromb Vasc Biol 27(11):2484–2490

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard C. Becker.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Becker, R.C. Platelet biology for the clinician-scientist: an evolution of understanding. J Thromb Thrombolysis 25, 235–237 (2008). https://doi.org/10.1007/s11239-008-0213-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-008-0213-2

Navigation