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Mutation-prone points in thrombin receptor

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Abstract

Background Thrombin receptor (TR) is a G-protein-coupled receptor that transmits cellular responses to coagulant proteases in a variety of cell types in the vasculature and other tissues. Mutation within TR can be seen. Presently, the prediction of protein nanostructure and function is a great challenge in the proteomics and structural genomics era. Methods To identify the points vulnerable to mutation is a new trend directed at expanding the knowledge on disorders in genomic and proteomic levels of diseases. In this paper, the author performed a bioinformatics analysis to find the mutation-prone positions in the amino acid sequence of TR. To identify those points in TR, a new bioinformatics tool, namely, GlobPlot was used. Results According to this work, no position was identified to be resistant to mutation. Conclusion This means that TR is a very highly genetically unstable molecule. Thousands of types of mutation can be expected. Of interest, only a few sense mutations are mentioned in clinical settings. Therefore, many occulted sense mutations might still be detected.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand

    Viroj Wiwanitkit

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  1. Viroj Wiwanitkit
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Correspondence to Viroj Wiwanitkit.

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Wiwanitkit, V. Mutation-prone points in thrombin receptor. J Thromb Thrombolysis 25, 190–192 (2008). https://doi.org/10.1007/s11239-007-0167-9

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  • DOI: https://doi.org/10.1007/s11239-007-0167-9

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