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G20210A Prothrombin gene variant in Turkish patients with angiographically documented coronary artery disease

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Abstract

Background

G→A substitution at position 20210A in the 3′-untranslated region in prothrombin gene is associated with raised plasma prothrombin. G20210A prothrombin variant has been associated with high prothrombin levels and an increased risk of venous thrombosis. To determine the prevalence of the G20210A prothrombin variant among Turkish and to evaluate the potential relevance of this variant to Turkish patients with angiographically documented coronary artery disease (CAD).

Methods

We conducted a case-control study on 268 unrelated subjects who referred to the cardiology department of the university hospital for coronary angiography. One hundred-thirty seven patients with angiographically documented CAD and 131 subjects without angiographically documented CAD were studied to examine the association of the G20210A prothrombin variant with CAD. Blood samples from the patients and controls were analyzed for the G20210A prothrombin variant by DNA analysis, using polimeraz chain reaction.

Results

G20210A prothrombin variant was found in 6 of 137 (4.4%) patients with CAD and 1 of 131 (0.8%) in control subjects (p = 0.064). There were no significant differences in terms of diabetes mellitus, hypertension, dyslipidemia, sex and family history of CAD with and without the G20210A prothrombin variant in the patient group.

Conclusions

In agreement with the results of recent meta-analyses, our data from northeast Anatolia show a 5-fold higher prevalence of the G20210A prothrombin variant among the patients with angiographically-documented CAD when compared with those without angiographic signs of significant CAD and its variant cannot be considered as a risk factor for CAD in this region.

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Acknowledgments

This study was supported by grants from the Ataturk University (BAP:2003/125), Erzurum, Turkey.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Ataturk Universit, Tıp Fakültesi Aziziye Araştırma Hastanesi Kardiyoloji Servisi, Erzurum, 25070, Turkey

    Fuat Gundogdu, Yekta Gurlertop, Sakir Arslan & Yahya Islamoglu

  2. Medical Biology and Genetics, Faculty of Medicine, Ataturk University, Erzurum, Turkey

    Ibrahim Pirim & Mevlut Ikbal

  3. Depatment of Bichemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey

    Hulya Aksoy

  4. Depatment of Cardiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey

    Huseyin Senocak

Authors
  1. Fuat Gundogdu
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  2. Yekta Gurlertop
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  3. Ibrahim Pirim
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  4. Sakir Arslan
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  6. Yahya Islamoglu
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Correspondence to Fuat Gundogdu.

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Gundogdu, F., Gurlertop, Y., Pirim, I. et al. G20210A Prothrombin gene variant in Turkish patients with angiographically documented coronary artery disease. J Thromb Thrombolysis 24, 255–259 (2007). https://doi.org/10.1007/s11239-007-0019-7

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  • DOI: https://doi.org/10.1007/s11239-007-0019-7

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