Advertisement

The mean platelet volume in gestational diabetes

  • Nuray BozkurtEmail author
  • Ercan Yılmaz
  • Aydan Biri
  • Zeki Taner
  • Özdemir Himmetoğlu
Clinical Trials

Abstract

Objective: To compare the platelet count and mean platelet volume (MPV) values of pregnancies diagnosed with gestational diabetes with those of healthy pregnancies.

Material—method: Between June 2003 and September 2004, 100 healthy pregnancies and 100 pregnancies with gestational diabetes were studied at Gazi University, Department of Obstetrics and Gynecology.

Results: While no statistically significant difference was observed in the platelet count between the two groups, the MPV of the gestational diabetes group (9.4 ± 1.6 fl) was evaluated to be significantly higher than the MPV of the healthy pregnancy group (8.3 ± 1.1 fl). Additionally, when linear regression analysis was performed an inverse relationship was observed between platelet number and MPV.

Conclusion: There is a need for further research focusing on the platelet function in the observation and treatment of gestational diabetes, which can pose the risk of developing Type 2 diabetes for the mother and has negative consequences for the fetus.

Keywords

Mean platelet volume Gestational diabetes 

References

  1. 1.
    Hyer SL, Shehata HA (2005) Gestational diabetes mellitus. Current Obstet Gynecol 15:368–374CrossRefGoogle Scholar
  2. 2.
    Gabbe SG, Graves CR (2003) Management of diabetes mellitus complicating pregnancy. Obstet Gynecol 102(4):857–868PubMedCrossRefGoogle Scholar
  3. 3.
    Jimenez-Moleon JJ, Bueno-Cavanillas A, Luna-Del-Castillo JD, Garcia-Martin M, Lardelli-Claret P, Galvez-Vargas R (2002) Prevalence of gestational diabetes mellitus: Variations related to screening strategy used. Eur J Endocrinol 146(6):831–837PubMedCrossRefGoogle Scholar
  4. 4.
    Hishinuma T, Tsukamoto H, Suzuki K, Mizugaki M (2001) Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. Prostaglandins Leukot Essent Fatty Acids 65(4):191–196PubMedCrossRefGoogle Scholar
  5. 5.
    Mazzanfi L, Mutus B (1997) Diabetes-induced alterations in platelet metabolism. Clinical Biochemistry 30(7):509–515CrossRefGoogle Scholar
  6. 6.
    Cay S, Bıyıkoglu F, Cihan G, Korkmaz S (2005) Mean platelet volume in the patients with cardiac syndrome X. Journal of Thrombosis and Thrombolysis 20:175–178PubMedCrossRefGoogle Scholar
  7. 7.
    Martin JF, Trowbridge EA, Salmon G, Plumb J (1983) The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thrombosis Research 1(32):443–460Google Scholar
  8. 8.
    Hekimsoy Z, Payzin B, Örnek T, Kandoğan G (2004) Mean platelet volume in type 2 diabetic patients. J Diabet Complications 18:173–176CrossRefGoogle Scholar
  9. 9.
    Saigo K, Yasunaga M, Ryo R (1992) Mean platelet volume in diabetics. Rinsha Byar 40(2):215–217 (Abstract)Google Scholar
  10. 10.
    Tschope D, Langer E, Schauseil S, Rosen P, Kaufmann L, Gries FA (1989) Increased platelet volume sign of impaired thrombopoiesis in diabetes mellitus. Klin Wochenschr 67(4):253–259PubMedCrossRefGoogle Scholar
  11. 11.
    Sharpe PC, Trinick T (1993) Mean platelet volume in diabetes mellitus. Q J Med 86(11):739–742PubMedGoogle Scholar
  12. 12.
    Coban E, Bostan F, Ozdogan M (2006) The mean platelet volume in subjects with impaired fasting glucose. Platelets 17(1):67–69PubMedCrossRefGoogle Scholar
  13. 13.
    Greer IA, et al (1988) Increased platelet reactivity in pregnancy induced hypertension and uncomplicated diabetic pregnancy indication for antiplatelet therapy. BJOG. 95:1204–1206Google Scholar
  14. 14.
    Dadak C, Kefalides A, Sinzinger H, Weber G (1982) Reduced umbilical artery prostacyclin formation in complicated pregnancies. Am J Obstet Gynecol 144:792–795PubMedGoogle Scholar
  15. 15.
    Ylikorkola O, Maluka UM (1985) Prostacyclin and thromboxane in gynecology and obstetrics. Am J Obstet Gynecol 152:318–329Google Scholar
  16. 16.
    Watanabe Y, Kawada M, Kobayashi B (1987) Effect of insulin on murine megakaryocytopoiesis in a liquid culture system. Cell Struct Funct 12(3):311–316PubMedCrossRefGoogle Scholar
  17. 17.
    Jones RL, Paradise C, Peterson CM (1981) Platelet survival in patients with diabetes mellitus. Diabetes 30(6):486–489PubMedGoogle Scholar
  18. 18.
    Yin SM, Li YQ, Xie SF, Ma LP, Wu YD, Nie DN, Feng JH, Xu LZ (2005) Study on the variation of platelet function in pregnancy induced hypertension and gestational diabetes mellitus. Zhongua Fu Chan Ke Za Zhi 40(1):25–28 (Abstract)Google Scholar
  19. 19.
    Sobel BE, Schneider DJ (2004) Platelet function, coagulopathy, and impaired fibrinolysis in diabetes Cardiol Clin 22(4):511–526PubMedCrossRefGoogle Scholar
  20. 20.
    Saldeen P, Olofsson P, Laurini RN (2002) Structural, functional and circulatory placental changes associated with impaired glucose metabolism. Eur J Obstet Gynecol Reprod Biol 105(2):136–142PubMedGoogle Scholar
  21. 21.
    Alonso A, Soto I, Urgelles MF, Corte JR, Rodriguez MJ, Pinto CR (2002) Acquired and inherited thrombophilia in women with unexplained fetal losses. Am J Obstet Gynecol 187(5):1337–1342PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Nuray Bozkurt
    • 1
    • 2
    Email author
  • Ercan Yılmaz
    • 1
  • Aydan Biri
    • 1
  • Zeki Taner
    • 1
  • Özdemir Himmetoğlu
    • 1
  1. 1.Department of Gynecology and Obstetrics, Faculty of MedicineGazi UniversityTurkey
  2. 2.AnkaraTurkey

Personalised recommendations