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Non-catheter associated venous thrombosis in hemophilia A and B. A critical review of all reported cases

Journal of Thrombosis and Thrombolysis volume 21, pages 279–284 (2006)Cite this article

Abstract

All reported cases of non-catheter induced venous thrombosis in patients with hemophilia A or B have been carefully evaluated. A total of 27 cases were reported,12 patients with hemophilia A and 15 patients with hemophilia B. The age of patients varied between 9 and 67 years. There were 10 cases of deep vein thrombosis, 8 patients with pulmonary embolism accompanied or not by deep vein thrombosis, 5 cases of superficial vein thrombosis. In addition, there were 3 cases of thrombosis in unusual sites (1 retinal central vein thrombosis and 2 portal vein thrombosis). Finally, in one case, venous thrombosis was multiple. There was a fatality in a hemophilia B patient with pulmonary embolism.

The most frequent risk or triggering factor in hemophilia A was the administration of Feiba or rFVIIa concentrates in patients with inhibitors. Surgery together with Prothrombin Complex concentrates was the most frequent cause in hemophilia B patients. Congenital associated prothrombotic risk factors were present in two patients.

No or very few therapeutic procedures were initiated in these patients but for a suspension or reduction of concentrates infusion. In a few instances low molecular weight heparin was given for a few days. The frequent association of venous thrombosis with infusion of concentrates indicates the need for a careful evaluation of patients about to receive such therapy.

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Authors and Affiliations

  1. Department of Medical and Surgical Sciences, University of Padua Medical School, via Ospedale 105, 35128, Padua, Italy

    Antonio Girolami, Raffaella Scandellari, Ezio Zanon, Roberto Sartori & Bruno Girolami

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  1. Antonio Girolami
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  2. Raffaella Scandellari
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  3. Ezio Zanon
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  4. Roberto Sartori
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  5. Bruno Girolami
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Correspondence to Antonio Girolami.

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Girolami, A., Scandellari, R., Zanon, E. et al. Non-catheter associated venous thrombosis in hemophilia A and B. A critical review of all reported cases. J Thromb Thrombolysis 21, 279–284 (2006). https://doi.org/10.1007/s11239-006-6556-7

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