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The Post-thrombotic Syndrome: The Forgotten Morbidity of Deep Venous Thrombosis

Journal of Thrombosis and Thrombolysis volume 21, pages 41–48 (2006)Cite this article

Abstract

The postthrombotic syndrome (PTS) is the most common complication of deep venous thrombosis (DVT) yet has received little attention from clinicians and researchers. Clinically, PTS is characterized by chronic pain, swelling, heaviness and other signs in the affected limb. In severe cases, venous ulcers may develop. PTS is burdensome and costly to patients and society because of its high prevalence, severity and chronicity. Preventing DVT with the use of effective thromboprophylaxis in high-risk patients and settings and minimizing the risk of ipsilateral DVT recurrence are likely to reduce the frequency of PTS. Compression stockings worn daily after DVT appear to reduce the incidence and severity of PTS but questions regarding their use and effectiveness remain. Future research should focus on identifying patients at high risk for PTS, assessing the role of thrombolysis in preventing PTS and evaluating the optimal use of compression stockings in preventing and treating PTS. In addition, new therapies to treat PTS should be sought and evaluated.

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  1. Department of Medicine, McGill University, and Center for Clinical Epidemiology & Community Studies, Sir Mortimer B. Davis Jewish General Hospital, 3755 Cote Ste. Catherine, Room A-127, Montreal, Quebec, Canada, H3T 1E2

    Susan R. Kahn MD, MSc

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Kahn, S.R. The Post-thrombotic Syndrome: The Forgotten Morbidity of Deep Venous Thrombosis. J Thromb Thrombolysis 21, 41–48 (2006). https://doi.org/10.1007/s11239-006-5574-9

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Key Words

  • deep venous thrombosis
  • post-thrombotic syndrome
  • epidemiology