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Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review

Theoretical and Experimental Chemistry volume 57, pages 387–420 (2022)Cite this article

Enantioselective construction methods of chiral derivatives of α-tertiary amines using acyclic and cyclic trifluoromethylketimines are considered. The importance of a trifluoromethyl group in the structure of ketimine substrates for effective asymmetric addition of C-nucleophilic reagents in the presence of metal complex catalysts or organocatalysts is emphasized. The practical application of these chiral products in medicinal chemistry is covered.

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Authors and Affiliations

  1. Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine

    V. A. Sukach, V. M. Tkachuk & M. V. Vovk

  2. LLC Research and Production Enterprise “Enamine”, Kyiv, Ukraine

    V. A. Sukach

  3. Institute of Organic and Analytical Chemistry, University of Orleans, Orleans, France

    I. Gillaizeau

Authors
  1. V. A. Sukach
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  2. V. M. Tkachuk
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  3. I. Gillaizeau
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  4. M. V. Vovk
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Corresponding author

Correspondence to M. V. Vovk.

Additional information

Translated from Teoretychna ta Eksperymentalna Khimiya, Vol. 57, No. 6, pp. 333-355, November-December, 2021.

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Sukach, V.A., Tkachuk, V.M., Gillaizeau, I. et al. Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review. Theor Exp Chem 57, 387–420 (2022). https://doi.org/10.1007/s11237-022-09710-z

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  • DOI: https://doi.org/10.1007/s11237-022-09710-z

Keywords

  • ketimines
  • trifluoromethyl group
  • α-tertiary amines
  • nucleophilic addition
  • asymmetric synthesis
  • metal complex catalysis
  • organocatalysis