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Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review

Enantioselective construction methods of chiral derivatives of α-tertiary amines using acyclic and cyclic trifluoromethylketimines are considered. The importance of a trifluoromethyl group in the structure of ketimine substrates for effective asymmetric addition of C-nucleophilic reagents in the presence of metal complex catalysts or organocatalysts is emphasized. The practical application of these chiral products in medicinal chemistry is covered.

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Scheme 40

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Correspondence to M. V. Vovk.

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Translated from Teoretychna ta Eksperymentalna Khimiya, Vol. 57, No. 6, pp. 333-355, November-December, 2021.

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Sukach, V.A., Tkachuk, V.M., Gillaizeau, I. et al. Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review. Theor Exp Chem 57, 387–420 (2022). https://doi.org/10.1007/s11237-022-09710-z

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  • DOI: https://doi.org/10.1007/s11237-022-09710-z

Keywords

  • ketimines
  • trifluoromethyl group
  • α-tertiary amines
  • nucleophilic addition
  • asymmetric synthesis
  • metal complex catalysis
  • organocatalysis