Structural Chemistry

, Volume 24, Issue 1, pp 279–283

Uniaxial negative thermal expansion in crystals of tienoxolol

  • Béatrice Nicolaï
  • Ivo B. Rietveld
  • Maria Barrio
  • Nathalie Mahé
  • Josep-Lluís Tamarit
  • René Céolin
  • Christophe Guéchot
  • Jean-Marie Teulon
Original Research

Abstract

The thermal expansion of tienoxolol has been investigated by X-ray powder diffraction up to its melting temperature. The data indicate that the expansion is anisotropic and even negative in one direction of the unit cell. The supramolecular structure formed by hydrogen-bonds reflects that of a trellis, which explains the observed behavior of tienoxolol crystals.

Keywords

Drug Active pharmaceutical ingredient (API) Crystal structure Solid state 

Supplementary material

11224_2012_78_MOESM1_ESM.docx (17 kb)
Supplementary material 1 (DOCX 17 kb)

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Béatrice Nicolaï
    • 1
  • Ivo B. Rietveld
    • 1
  • Maria Barrio
    • 2
  • Nathalie Mahé
    • 1
  • Josep-Lluís Tamarit
    • 2
  • René Céolin
    • 1
  • Christophe Guéchot
    • 3
  • Jean-Marie Teulon
    • 4
  1. 1.Laboratoire de Chimie Physique, EAD Physico-chimie Industrielle du Médicament (EA4066), Faculté de PharmacieUniversité Paris DescartesParisFrance
  2. 2.Grup de Caracterització de Materials (GCM), Departament de Física i Enginyeria NuclearUniversitat Politècnica de Catalunya, ETSEIBBarcelonaSpain
  3. 3.Solvay SAParisFrance
  4. 4.La Celle Saint CloudFrance

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