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Metergoline II: structure solution from powder diffraction data with preferred orientation and from microcrystal

Structural Chemistry volume 19, pages 517–525 (2008)Cite this article

Abstract

Metergoline is a dopamine agonist and serotonin antagonist used both in human and veterinary medicine. In addition to the previously known crystalline form, a new polymorph, which crystallizes from aqueous solution, was found. Since it was initially impossible to prepare a single crystal of quality suitable for single crystal X-ray diffraction measurements using a conventional laboratory source, the structure was solved from the powder diffraction data using synchrotron radiation. The structure determination also included solving the effects of preferred orientation. Characterization was simultaneously done by solid-state NMR spectroscopy. Finally, a small single crystal suitable for synchrotron diffraction was found after numerous tries. Crystal structure determination using this single crystal confirmed the powder-based solution. Comparison of information obtained by different experimental methods (powder diffraction, ssNMR, single crystal diffraction) was made.

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Acknowledgments

This study was supported by the grant of the Czech Grant Agency (GAČR 203/07/0040), grant from the Grant Agency of the Academy of Sciences of the Czech Republic (IAA400500602) and by the research program MSM6046137302 of the Ministry of Education, Youth and Sports of the Czech Republic. We acknowledge the European Synchrotron Radiation Facility for provision of synchrotron radiation facilities and we would like to thank Denis Testemale for assistance in using beam line BM01B.

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Authors and Affiliations

  1. Department of Solid State Chemistry, Institute of Chemical Technology Prague, 166 28, Prague 6, Czech Republic

    Michal Hušák

  2. IVAX Pharmaceuticals, Research and Development, Branišovská 31, 370 05, Ceske Budejovice, Czech Republic

    Alexandr Jegorov

  3. Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovský Sq. 2, 162 06, Prague 6, Czech Republic

    Jiří Brus

  4. BM01B Beamline (Swiss-Norwegian), ESRF, 6 rue Jules Horowitz, BP 220, 38043, Grenoble Cedex, France

    Wouter van Beek & Philip Pattison

  5. Dipartamento di Scienze e Tecnologie Avanzate, Universita` del Piemonte Orientale, and NanoSistemi IC, Via Bellini 25/G, Alessandria, 15100, Itlay

    Wouter van Beek

  6. Laboratoire de Cristallographie, Ecole Polytechnique Federale de Lausanne, BSP – Dorigny, 1015, Lausanne, Switzerland

    Philip Pattison

  7. Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark

    Mogens Christensen

  8. Université Joseph Fourier, BP 53, 38041, Grenoble Cedex 9, France

    Vincent Favre-Nicolin

  9. CEA/DRFMC/SP2M, 17 rue des Martyrs, 38054, Grenoble Cedex 9, France

    Vincent Favre-Nicolin

  10. Central Laboratories, Institute of Chemical Technology Prague, 166 28, Prague 6, Czech Republic

    Jaroslav Maixner

Authors
  1. Michal Hušák
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  2. Alexandr Jegorov
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  3. Jiří Brus
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  4. Wouter van Beek
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  5. Philip Pattison
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  6. Mogens Christensen
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  7. Vincent Favre-Nicolin
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  8. Jaroslav Maixner
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Correspondence to Michal Hušák.

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Hušák, M., Jegorov, A., Brus, J. et al. Metergoline II: structure solution from powder diffraction data with preferred orientation and from microcrystal. Struct Chem 19, 517–525 (2008). https://doi.org/10.1007/s11224-008-9312-0

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  • DOI: https://doi.org/10.1007/s11224-008-9312-0

Keywords

  • Crystal structure
  • Metergoline
  • Powder diffraction
  • Preferred orientation