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Abstract

Chirality, meaning handedness, pervades much of modern science, from the physics of elementary particles to the chemistry of life. The amino acids and sugars from which the central molecules of life—proteins and nucleic acids—are constructed exhibit homochirality, which is expected to be a key biosignature in astrobiology. This article provides a brief review of molecular chirality and its significance for the detection of extant or extinct life on other worlds. Fundamental symmetry aspects are emphasized since these bring intrinsic physical properties of the universe to bear on the problem of the origin and role of homochirality in the living world.

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References

  • M. Avalos, R. Babiano, P. Cintas, J.L. Jiménez, J.C. Palacios, L.D. Barron, Chem. Rev. 98, 2391 (1998)

    Article  Google Scholar 

  • M. Avalos, R. Babiano, P. Cintas, J.L. Jiménez, J.C. Palacios, Orig. Life 34, 391 (2004a)

    Article  Google Scholar 

  • M. Avalos, R. Babiano, P. Cintas, J.L. Jiménez, J.C. Palacios, Tet. Asym. 15, 3171 (2004b)

    Article  Google Scholar 

  • V.A. Avetisov, V.I. Goldanskii, V.V. Kuz’min, Phys. Today, July, 33 (1991)

  • J.L. Bada, G.D. McDonald, Icarus 114, 139 (1995)

    Article  ADS  Google Scholar 

  • J. Bailey, A. Chryosostomou, J.H. Hough, T.M. Gledhill, A. McCall, S. Clark, F. Ménard, M. Tamura, Science 281, 672 (1998)

    Article  ADS  Google Scholar 

  • P. Ball, Nature 436, 1084 (2005)

    Article  ADS  Google Scholar 

  • L.D. Barron, J. Am. Chem. Soc. 108, 5539 (1986)

    Article  Google Scholar 

  • L.D. Barron, Chem. Phys. Lett. 135, 1 (1987)

    Article  ADS  Google Scholar 

  • L.D. Barron, Chem. Phys. Lett. 221, 311 (1994a)

    Article  ADS  Google Scholar 

  • L.D. Barron, Science 266, 1491 (1994b)

    Article  ADS  Google Scholar 

  • L.D. Barron, Nature 405, 895 (2000)

    Article  Google Scholar 

  • L.D. Barron, in Chirality in Natural and Applied Science, ed. by W.J. Lough, I.W. Wainer (Blackwell, Oxford, 2002), p. 53

    Google Scholar 

  • L.D. Barron, Molecular Light Scattering and Optical Activity, 2nd edn (Cambridge University Press, Cambridge, 2004)

  • L.D. Barron, F. Zhu, L. Hecht, G.E. Tranter, N.W. Isaacs, J. Mol. Struct. 834, 7 (2007)

    Article  ADS  Google Scholar 

  • J.-P. Behr (ed.) The Lock and Key Principle (Wiley, New York, 1994)

    Google Scholar 

  • V.B. Berestetskii, E.M. Lifshitz, L.P. Pitaevskii, Quantum Electrodynamics (Pergamon, Oxford, 1982)

    Google Scholar 

  • W.A. Bonner, Top. Stereochem. 18, 1 (1988)

    Article  Google Scholar 

  • M.A. Bouchiat, C. Bouchiat, Rep. Prog. Phys. 60, 1351 (1997)

    Article  ADS  Google Scholar 

  • A. Brack, Adv. Space Res. 24, 417 (1999)

    Article  ADS  Google Scholar 

  • P. Cintas, Ang. Chem. Int. Ed. 41, 1139 (2002)

    Article  Google Scholar 

  • R.N. Compton, R.M. Pagni, Adv. At. Mol. Opt. Phys. 48, 219 (2002)

    Google Scholar 

  • J.J.L.M. Cornelissen, A.E. Rowan, R.J.M. Nolte, N.A.J.M. Sommerdijk, Chem. Rev. 101, 4039 (2001)

    Article  Google Scholar 

  • J.R. Cronin, S. Pizzarello, Science 275, 951 (1997)

    Article  ADS  Google Scholar 

  • P. Curie, J. Phys. (Paris) 3, 393 (1894)

    Google Scholar 

  • B.L. Feringa, R.A. van Delden, Angew. Chem. Int. Ed. 38, 3418 (1999)

    Article  Google Scholar 

  • N. Fujii, Orig. Life 32, 103 (2002)

    Article  Google Scholar 

  • K. Gottfried, V.F. Weisskopf, Concepts of Particle Physics, vol. 1 (Clarendon Press, Oxford, 1984)

  • M.M. Green, N.C. Peterson, T. Sato, A. Teramoto, R. Cook, S. Lifson, Science 268, 1860 (1995)

    Article  ADS  Google Scholar 

  • R.M. Hazen, T.R. Filley, G.A. Goodfriend, Proc. Natl. Acad. Sci. USA 98, 5487 (2001)

    Article  ADS  Google Scholar 

  • R.A. Hegstrom, D.W. Rein, P.G.H. Sandars, J. Chem. Phys. 73, 2329 (1980)

    Article  ADS  Google Scholar 

  • F.M. Jaeger, Optical Activity and High-Temperature Measurements (McGraw-Hill, New York, 1930)

    Google Scholar 

  • G.F. Joyce, G.M. Visser, C.A.A. van Boeckel, J.H. van Boom, L.E. Orgel, J. van Westresen, Nature 310, 602 (1984)

    Article  ADS  Google Scholar 

  • Lord Kelvin, Baltimore Lectures (C.J. Clay & Sons, London, 1904)

    MATH  Google Scholar 

  • L. Keszthelyi, Quart. Rev. Biophys. 28, 473 (1995)

    Article  Google Scholar 

  • M. Klussman, H. Iwamura, S.P. Mathew, D.H. Wells Jr., U. Pandya, A. Armstrong, D.G. Blackmond, Nature 441, 621 (2006)

    Article  ADS  Google Scholar 

  • D.K. Kondepudi, K. Asakura, Accs. Chem. Res. 34, 946 (2001)

    Article  Google Scholar 

  • R. Konno, H. Brückner, A. D’Aniello, G.H. Fisher, N. Fujii, H. Homma (eds.), D-Amino Acids: A New Frontier in Amino Acid and Protein Research – Practical Methods and Protocols (Nova Science Publishers, New York, 2007)

    Google Scholar 

  • M. Lahav, I. Weissbuch, E. Shavit, C. Reiner, G.J. Nicholson, V. Schurig, Orig. Life 36, 151 (2006)

    Google Scholar 

  • A.J. MacDermott, in Chirality in Natural and Applied Science, ed. by W.J. Lough, I.W. Wainer (Blackwell, Oxford, 2002), p. 23

    Google Scholar 

  • S.F. Mason, Chem. Soc. Rev. 17, 347 (1988)

    Article  Google Scholar 

  • U.J. Meierhenrich, L. Nahon, C. Alcarez, J.H. Bredehöft, S.V. Hoffman, B. Barbier, A. Brack, Ang. Chem. Int. Ed. 44, 5630 (2005)

    Article  Google Scholar 

  • C.A. Orme, A. Noy, A. Wierzbicki, M.T. McBride, M. Grantham, H.H. Teng, P.M. Dove, J.J. DeYoreo, Nature 411, 775 (2001)

    Article  ADS  Google Scholar 

  • R.M. Pagni, R.N. Compton, Cryst. Growth Des. 2, 249 (2002)

    Article  Google Scholar 

  • L. Pasteur, Bull. Soc. Chim. France 41, 219 (1884)

    Google Scholar 

  • R.H. Perry, C. Wu, M. Nefliu, R.G. Cooks, Chem. Commun., 2007, p. 1071

  • S. Pizzarello, Accs. Chem. Res. 39, 231 (2006)

    Article  Google Scholar 

  • S. Pizzarello, M. Zolensky, K.A. Turk, Geochim. Cosmochim. Acta 67, 1589 (2003)

    Article  ADS  Google Scholar 

  • J. Popp, M. Schmitt, J. Raman Spectrosc. 35, 429 (2004)

    Article  ADS  Google Scholar 

  • M. Quack, Ang. Chem. Int. Ed. 41, 4618 (2002)

    Article  Google Scholar 

  • G.L.J.A. Rikken, E. Raupach, Nature 405, 932 (2000)

    Article  ADS  Google Scholar 

  • I. Rubinstein, R. Eliash, G. Bolbach, I. Weissbuch, M. Lahav, Ang. Chem. Int. Ed. 46, 1 (2007)

    Article  Google Scholar 

  • A.M. Skelley, R.A. Mathies, J. Chromatogr. A1021, 191 (2003)

    Article  Google Scholar 

  • W.B. Sparks, J.H. Hough, L.E. Bergeron, Astrobiology 5, 737 (2005)

    Article  ADS  Google Scholar 

  • G.H. Wagnière, A. Meir, Chem. Phys. Lett. 93, 78 (1982)

    Article  ADS  Google Scholar 

  • R. Wesendrup, J.K. Laerdahl, R.N. Compton, P. Schwerdtfeger, J. Phys. Chem. A 107, 6668 (2003)

    Article  Google Scholar 

  • I. Weissbuch, L. Leiserowitz, M. Lahav, Top. Curr. Chem. 259, 123 (2005)

    Article  Google Scholar 

  • E. Westhof (ed.), Water and Biological Macromolecules (CRC, Boca Raton, 1993)

    Google Scholar 

  • D.C.B. Whittet, Dust in the Galactic Environment (Institute of Physics Publishing, Bristol, 1992)

    Google Scholar 

  • R.D. Wolstencroft, G.E. Tranter, D.D. Le Pevelen, IAU Symp. 213, 149 (2002)

    ADS  Google Scholar 

Download references

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Correspondence to Laurence D. Barron.

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Barron, L.D. Chirality and Life. Space Sci Rev 135, 187–201 (2008). https://doi.org/10.1007/s11214-007-9254-7

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  • DOI: https://doi.org/10.1007/s11214-007-9254-7

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