Abstract
The major goal of this review is to assess food risks of the introduction of genetically modified (GM) crops. The author analyzes the properties of the several classes of target proteins used in the transgenic constructions and discusses the problems that arise due to the pleiotropic action of transgenic proteins, the horizontal transfer of the transgenic constructions, primarily in bacteria, and their instability. Particular consideration is given to elevated risks of using the GM plant varieties for producing pharmaceutical preparations, due to the probability of uncontrolled cross-pollination between the GM plants and the plants grown for foodstuff production. The author emphasizes the requirement for assessing in detail all hypothetic risks in each particular case of cultivating GM varieties; as a control, such assessment must involve a comprehensive comparison with the conventional parental forms.
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Abbreviations
- GM:
-
genetically modified
- GMO:
-
genetically modified organisms
- RIP:
-
ribosome-inactivating proteins
REFERENCES
Sokolov, M.S., Vel’kov, V.V., and Medvinskii, A.B., State Control over Transgenic Plants and the Assessment of Ecological Risks of Their Production, Obespechenie ekologicheskoi bezopasnosti pri ispol‘zovanii geneticheski modifitsirovannykh organizmov (The Guarantee of Ecological Safety of the Usage of Modified Organisms), Moscow, 2002, pp. 17–27.
M. Giovannetti (2003) ArticleTitleThe Ecological Risks of Transgenic Plants Riv. Biol. 96 207–223
H.I. Miller (1983) ArticleTitleReport on the World Health Organization Working Group on Health Implications of Biotechnology Recomb. DNA Tech. Bull. 6 65–66
J.C. Petricciani (1983) ArticleTitleAn Overview of Safety and Regulatory Aspects of the New Biotechnology Regul. Toxicol. Pharmacol. 3 428–433
Coordinated Framework for Regulation of Biotechnology: Announcement of Policy and Notice for Public Comment, Office of Science and Technology Policy, U.S. Fed. Reg., 1986, vol. 51, pp. 23302–23350.
S.W. Ewen A. Pusztai (1999) ArticleTitleEffect of Diets Containing Genetically Modified Potatoes Expressing Galanthus nivalis Lectin on Rat Small Intestine Lancet 354 1353–1354
A. Pusztai G.G. Bardocz R. Alonso M.J. Chrispeels H.E. Schroeder L.M. Tabe T.J. Higgins (1999) ArticleTitleExpression of the Insecticidal Bean Alpha-Amylase Inhibitor Transgene Has Minimal Detrimental Effect on the Nutritional Value of Peas Fed to Rats at 30% of the Diet J. Nutr. 129 1597–1603
S.W. Ewen A. Pusztai (1999) ArticleTitleHealth Risks of Genetically Modified Foods Lancet 354 684–684
H.S. Mason J.M. Ball J.J. Shi X. Jiang M.K. Estes C.J. Arntzen (1996) ArticleTitleExpression of Norwalk Virus Capsid Protein in Transgenic Tobacco and Potato and Its Oral Immunogenicity in Mice Proc. Natl. Acad. Sci. USA 93 5335–5340
D.L. Skea P. Christopoulous A.G. Plaut B.J. Underdown (1988) ArticleTitleStudies on the Specificity of the IgA-Binding Lectin, Jacalin Mol. Immunol. 25 1–6
V.O. Antoniuk (1992) ArticleTitleIsolation of Lectin from Horse Chestnut (Aesculus hippocastanum, L.) Seeds and Study of Its Interaction with Carbohydrates and Glycoproteins Ukr. Biokhim. Zh. 64 47–52
InstitutionalAuthorNameBINAS Monitor (1999) BINAS News 5 12–19
F. Gabor M. Stangl M. Wirth (1998) ArticleTitleLectin-Mediated Bioadhesion: Binding Characteristics of Plant Lectins on the Enterocyte-Like Cell Lines Caco-2, HT-29, and HCT-8 J. Control Release 55 131–142
B. Fenton K. Stanley S. Fenton C. Bolton-Smith (1999) ArticleTitleDifferential Binding of the Insecticidal Lectin GNA to Human Blood Cells Lancet 354 1354–1355
T.G. Lauterslager D.E. Florack T.J. Wal Particlevan der J.W. Molthoff J.P. Langeveld D. Bosch W.J. Boersma L.A. Hilgers (2001) ArticleTitleOral Immunisation of Naive and Primed Animals with Transgenic Potato Tubers Expressing LT-B Vaccine 19 2749–2755
R.J. Dearman H. Caddick S. Stone D.A. Basketter I. Kimber (2001) ArticleTitleCharacterization of Antibody Responses Induced in Rodents by Exposure to Food Proteins: Influence of Route of Exposure Toxicology 167 217–231
P.J. Dale (1999) ArticleTitlePublic Concerns over Transgenic Crops Genome Res. 9 1159–1162
N.G. Halford P.R. Shewry (2000) ArticleTitleGenetically Modified Crops: Methodology, Benefits, Regulation and Public Concerns Br. Med. Bull. 56 62–73
Bacillus thuringiensis Subspecies tolworthi Cry9c Protein and the Genetic Material Necessary for Its Production in Corn: Exemption from the Requirement of a Tolerance, U.S. Environmental Protection Agency, U.S. Fed. Reg., 1998, vol. 63, pp. 28258–28261.
Assessment of Scientific Information Concerning Star-Link Corn Cry9C Bt Corn Plant—Pesticide, Docket PF-867B, U.S. Environmental Protection Agency, U.S. Fed Reg., 2000, vol. 65, pp. 65 245–65 251.
H. Okunuki R. Teshima T. Shigeta J. Sakushima H. Akiyama Y. Goda M. Toyoda J. Sawada (2002) ArticleTitleIncreased Digestibility of Two Products in Genetically Modified Food (CP4-EPSPS and Cry1Ab) after Preheating Shokuhin Eiseigaku Zasshi 43 68–73
R. Teshima T. Watanabe H. Okunuki K. Isuzugawa H. Akiyama H. Onodera T. Imai M. Toyoda J. Sawada (2002) ArticleTitleEffect of Subchronic Feeding of Genetically Modified Corn (CBH351) on Immune System in BN Rats and B10A Mice Shokuhin Eiseigaku Zasshi 43 273–279
R.H. Phipps E.R. Deaville B.C. Maddison (2003) ArticleTitleDetection of Transgenic and Endogenous Plant DNA in Rumen Fluid, Duodenal Digesta, Milk, Blood, and Feces of Lactating Dairy Cows J. Dairy Sci. 86 4070–4078
I.L. Bernstein J.A. Bernstein M. Miller S. Tierzieva D.I. Bernstein Z. Lummus M.K. Selgrade D.L. Doerfler V.L. Seligy (1999) ArticleTitleImmune Responses in Farm Workers after Exposure to Bacillus thuringiensis Pesticides Environ. Health Perspect. 107 575–582
R.I. Vazquez-Padron L. Moreno-Fierros L. Neri-Bazan A.F. Martinez-Gil G.A. de-la-Riva R. Lopez-Revilla (2000) ArticleTitleCharacterization of the Mucosal and Systemic Immune Response Induced by Cry1Ac Protein from Bacillus thuringiensis HD 73 in Mice Braz. J. Med. Biol. Res. 33 147–155
J.A. Bernstein I.L. Bernstein L. Bucchini L.R. Goldman R.G. Hamilton S. Lehrer C. Rubin H.A. Sampson (2003) ArticleTitleClinical and Laboratory Investigation of Allergy to Genetically Modified Foods Environ. Health Perspect. 111 1114–1121
R.B. Raybourne K.M. Williams R. Vogt D.B. Reissman B.S. Winterton C. Rubin (2003) ArticleTitleDevelopment and Use of an ELISA Test to Detect IgE Antibody to Cry9c Following Possible Exposure to Bioengineered Corn Int. Arch. Allergy Immunol. 132 322–328
K. Andersson J. Lidholm (2003) ArticleTitleCharacteristics and Immunobiology of Grass Pollen Allergens Int. Arch. Allergy Immunol. 130 87–107
D.I. Oltean A.K. Pullikuth H.K. Lee S.S. Gill (1999) ArticleTitlePartial Purification and Characterization of Bacillus thuringiensis Cry1A Toxin Receptor A from Heliothis virescens and Cloning of the Corresponding cDNA Appl. Environ. Microbiol. 65 4760–4766
R. Rajagopal N. Agrawal A. Selvapandiyan S. Sivakumar S. Ahmad R.K. Bhatnagar (2003) ArticleTitleRecombinantly Expressed Isoenzymic Aminopeptidases from Helicoverpa armigera (American Cotton Bollworm) Midgut Display Differential Interaction with Closely Related Bacillus thuringiensis Insecticidal Proteins Biochem. J. 370 971–978
L. Bucchini L.R. Goldman (2002) ArticleTitleStarLink Corn: A Risk Analysis Environ. Health Perspect. 110 5–13
P.A. Orlandi K.A. Lampel P.K. South S.K. Assar L. Carter D.D. Levy (2002) ArticleTitleAnalysis of Flour and Food Samples for Cry9C from Bioengineered Corn J. Food Prot. 65 426–431
R. Brodzik H. Koprowski V. Yusibov A. Sirko (2000) ArticleTitleProduction of Urease from Helicobacter pylori in Transgenic Tobacco Plants Cell Mol. Biol. 5 357–366
C. Follmer G.B. Barcellos R.B. Zingali O.L. Machado E.W. Alves C. Barja-Fidalgo J.A. Guimaraes C.R. Carlini (2001) ArticleTitleCanatoxin, a Toxic Protein from Jack Beans (Canavalia ensiformis), Is a Variant Form of Urease (EC 3.5.1.5): Biological Effects of Urease Independent of Its Ureolytic Activity Biochem. J. 360 217–224
C.R. Carlini M.F. Grossi-de-Sa (2002) ArticleTitlePlant Toxic Proteins with Insecticidal Properties: A Review on Their Potentialities as Bioinsecticides Toxicon 40 1515–1539
C.R. Carlini J.A. Guimaraes (1991) ArticleTitlePlant and Microbial Toxic Proteins as Hemilectins: Emphasis on Canatoxin Toxicon 29 791–806
Kawata, M., Inspection of the Safety Assessment of Genetically Modified, the Roundup Tolerant Soybean: Monsanto’s Dangerous Logic as Seen in the Application Document Submitted to Japan, 2001, http://www.biotech-info.net/safety-inspection2.html.
Navarro, G.H., Lopez, C.C., Garcia, E., and Forat, S.M., Field Evaluation of a Fullfat Soybean Meal Obtained with the Use of an Expander in Commercial Broiler Rations, FE/SBM, 2001, vol. 107, 2001-E, http://www.asa-europe.org/online/Navarro_ExFFSBM.pdf.
C.P. Witte S.A. Tiller M.A. Taylor H.V. Davies (2002) ArticleTitleLeaf Urea Metabolism in Potato: Urease Activity Profile and Patterns of Recovery and Distribution of (15)N after Foliar Urea Application in Wild-Type and Urease-Antisense Transgenics Plant Physiol. 128 1129–1136
H. Holm A. Jorgensen L.E. Hanssen (1991) ArticleTitleRaw Soy, and Purified Proteinase Inhibitors Induce the Appearance of Inhibitor-Resistant Trypsin and Chymotrypsin Activities in Wistar Rat Duodenal Juice J. Nutr. 121 532–538
B.J. Struthers J.R. MacDonald (1983) ArticleTitleComparative Inhibition of Trypsins from Several Species by Soybean Trypsin Inhibitors J. Nutr. 113 800–804
J.E. Reseland H. Holm M.B. Jacobsen T.G. Jenssen L.E. Hanssen (1996) ArticleTitleProteinase Inhibitors Induce Selective Stimulation of Human Trypsin and Chymotrypsin Secretion J. Nutr. 126 634–642
A. Krogdahl H. Holm (1981) ArticleTitleSoybean Proteinase Inhibitors and Human Proteolytic Enzymes: Selective Inactivation of Inhibitors by Treatment with Human Gastric Juice J. Nutr. 111 2045–2051
A.L. Tan-Wilson K.A. Wilson (1986) ArticleTitleRelevance of Multiple Soybean Trypsin Inhibitor Forms to Nutritional Quality Adv. Exp. Med. Biol. 199 391–411
Liener, I.E., Possible Adverse Effects of Soybean Anticarcinogens, J. Nutr., 1995, p. 125.
I.E. Liener R.L. Goodale A. Deshmukh T.L. Satterberg G. Ward C.M. DiPietro P.E. Bankey J.W. Borner (1988) ArticleTitleEffect of a Trypsin Inhibitor from Soybeans (Bowman-Birk) on the Secretory Activity of the Human Pancreas Gastroenterology 94 419–427
J.T. Christeller E.P. Burgess V. Mett H.S. Gatehouse N.P. Markwick C. Murray L.A. Malone M.A. Wright B.A. Philip D. Watt L.N. Gatehouse G.L. Lovei A.L. Shannon M.M. Phung L.M. Watson W.A. Laing (2002) ArticleTitleThe Expression of a Mammalian Proteinase Inhibitor, Bovine Spleen Trypsin Inhibitor in Tobacco and Its Effects on Helicoverpa armigera Larvae Transgenic Res. 11 161–173
I. Suehiro M. Otsuki T. Yamasaki A. Ohki C. Sakamoto H. Yuu M. Maeda S. Baba (1981) ArticleTitleEffect of Alpha-Glucosidase Inhibitor on Human Pancreatic and Salivary Alpha-Amylase Clin. Chim. Acta 117 145–152
H. Yoshikawa M. Kotaru C. Tanaka T. Ikeuchi M. Kawabata (1999) ArticleTitleCharacterization of Kintoki Bean (Phaseolus vulgaris) Alpha-Amylase Inhibitor: Inhibitory Activities against Human Salivary and Porcine Pancreatic Alpha-Amylases and Activity Changes by Proteolytic Digestion J. Nutr. Sci. Vitaminol. 45 797–802
M. Kusaba-Nakayama M. Ki E. Kawada M. Sato I. Ikeda T. Mochizuki K. Imaizumi (2001) ArticleTitleIntestinal Absorbability of Wheat Allergens, Subunits of a Wheat Alpha-Amylase Inhibitor, Expressed by Bacteria Bio-Sci. Biotech. Biochem. 65 2448–2455
O.L. Franco D.J. Rigden F.R. Melo M.F. Grossi-de-Sa (2002) ArticleTitlePlant-Amylase Inhibitors and Their Interaction with Insect Amylases: Structure, Function and Potential for Crop Protection Eur. J. Biochem. 269 397–412
B. Svensson K. Fukuda P.K. Nielsen B.C. Bonsager (2004) ArticleTitleProteinaceous Amylase Inhibitors Biochim. Biophys. Acta 1696 145–156
C. Fabre H. Causse L. Mourey J. Koninkx M. Riviere H. Hendriks G. Puzo J.P. Samama P. Rouge (1998) ArticleTitleCharacterization and Sugar-Binding Properties of Arcelin-1, an Insecticidal Lectin-Like Protein Isolated from Kidney Bean (Phaseolus vulgaris L. cv. RAZ-2) Seeds Biochem. J. 329 551–560
K. Nielsen R.S. Boston (2001) ArticleTitleRibosome-Inactivating Proteins: A Plant Perspective Annu. Rev. Plant Physiol. Plant Mol. Biol. 52 785–816
S.-W. Park N.M. Stevens J.M. Vivanco (2002) ArticleTitleEnzymatic Specificity of Three Ribosome-Inactivating Proteins against Fungal Ribosomes, and Correlation with Antifungal Activity Planta 216 227–234 Occurrence Handle10.1007/s00425-002-0851-0 Occurrence Handle1:CAS:528:DC%2BD3sXktFOisA%3D%3D Occurrence Handle12447536
S. Desmyter F. Vandenbussche Q. Hao P. Proost W.J. Peumans E.J. Damme Particlevan (2003) ArticleTitleType-1 Ribosome-Inactivating Protein from Iris Bulbs: A Useful Agronomic Tool to Engineer Virus Resistance? Plant. Mol. Biol. 51 567–576
W.J. He W.Y. Liu (2003) ArticleTitleCinnamomin: A Multifunctional Type II Ribosome-Inactivating Protein Int. J. Biochem. Cell Biol. 35 1021–1027
J.C. Aub B.H. Sanford M.N. Cote (1965) ArticleTitleStudies on Reactivity of Tumor and Normal Cells to a Wheat Germ Agglutinin Proc. Natl. Acad. Sci. USA 54 396–399
J.C. Aub B.H. Sanford L.H. Wang (1965) ArticleTitleReactions of Normal and Leukemic Cell Surfaces to a Wheat Germ Agglutinin Proc. Natl. Acad. Sci. USA 54 400–402
C. Summers J. Forrest M. Norval J. Michael Sharp (2002) ArticleTitleThe Potentially Insecticidal Narcissus pseudo-narcissus Lectin Demonstrates Age-Related Mitogenicity FEMS Immunol. Med. Microbiol. 33 47–49
J.A. Nordlee S.L. Taylor J.A. Townsend L.A. Thomas R.K. Bush (1996) ArticleTitleIdentification of Brazil Nut Allergen in Transgenic Soybeans N. Engl. J. Med. 334 666–692
Lehrer, S.B., Potential Health Risks of Genetically Modified Organisms: How Can Allergens Be Assessed and Minimized, Agricultural Biotechnology and the Poor. Consultative Group on International Agricultural Research, Persley, G.J. and Lantin, M.M., Eds., Washington (DC), 2000, pp. 149–155.
V.A. Hilder D. Boulter (1999) ArticleTitleGenetic Engineering of Crop Plants for Insect Resistance: A Critical Review Crop Prot. 18 177–191
A. Herrera-Estrella I. Chet (1999) ArticleTitleChitinases in Biological Control EXS 87 171–184
K. Datta N. Baisakh K.M. Thet J. Tu S.K. Datta (2002) ArticleTitlePyramiding Transgenes for Multiple Resistance in Rice against Bacterial Blight, Yellow Stem Borer and Sheath Blight Theor. Appl. Genet. 106 1–8
Y. Itoh K. Takahashi H. Takizawa N. Nikaidou H. Tanaka H. Nishihashi T. Watanabe Y. Nishizawa (2003) ArticleTitleFamily 19 Chitinase of Streptomyces griseus HUT6037 Increases Plant Resistance to the Fungal Disease BioSci. Biotech. Biochem. 67 847–855
J.K. Kim I.C. Jang R. Wu W.N. Zuo R.S. Boston Y.H. Lee I.P. Ahn B.H. Nahm (2003) ArticleTitleCo-Expression of a Modified Maize Ribosome-Inactivating Protein and a Rice Basic Chitinase Gene in Transgenic Rice Plants Confers Enhanced Resistance to Sheath Blight Transgenic Res. 12 475–484
G. Wu B.J. Shortt E.B. Lawrence J. Leon K.C. Fitzsimmons E.B. Levine I. Raskin D.M. Shah (1997) ArticleTitleActivation of Host Defense Mechanisms by Elevated Production of H2O2 in Transgenic Plants Plant Physiol. 115 427–435
F. Esposito V. Fogliano T. Cardi D. Carputo E. Filippone (2002) ArticleTitleGlycoalkaloid Content and Chemical Composition of Potatoes Improved with Nonconventional Breeding Approaches J. Agric. Food Chem. 50 1553–1561
A. Anand T. Zhou H.N. Trick B.S. Gill W.W. Bockus S. Muthukrishnan (2003) ArticleTitleGreenhouse and Field Testing of Transgenic Wheat Plants Stably Expressing Genes for Thaumatin-Lke Protein, Chitinase and Glucanase against Fusarium graminearum J. Exp. Bot. 54 1101–1111
S.A. Palacios (2001) ArticleTitleLatex Allergy: Diagnosis and Therapeutic Aspects Allergol. Immunopathol. 29 212–221
Sussman, G.L., Beezhold, D.H., and Kurup, V.P., Allergens and Natural Rubber Proteins, J. Allergy Clin. Immunol., 2002, p. 110.
Down, P.F., Herms, D.A., Berhof, M.A., and Lagrimini, L.M., Mechanisms of Insect Resistance in Transgenic Plants (Over)Expressing a Tobacco Anionic Peroxidase, Plant Peroxidase Newslett., 2000, no. 14, pp. 93–101.
K. Hoffmann-Sommergruber (2002) ArticleTitlePathogenesis-Related (PR)-Proteins Identified as Allergens Biochem. Soc. Trans. 30 930–935
A. Cantani M. Micera (2001) ArticleTitleGenetically Modified Foods and Children Potential Health Risks Eur. Rev. Med. Pharmacol. Sci. 5 25–29
R.D. Wauchope T.L. Estes R. Allen J.L. Baker A.G. Hornsby R.L. Jones R.P. Richards D.I. Gustafson (2002) ArticleTitlePredicted Impact of Transgenic, Herbicidetolerant Corn on Drinking Water Quality in Vulnerable Watersheds of the Mid-Western USA Pest. Manag. Sci. 58 146–160
L. Hardell M.A. Eriksson (1999) ArticleTitleCase-Control Study of Non-Hodgkin Lymphoma and Exposure to Pesticides Cancer 85 1353–1360
Felsot, A., Herbicide Tolerant Genes: 1. Squaring up Roundup Ready Crops, Agrichem. Environ. News, 2000, no. 173, http://www.aenews.wsu.edu/ Sept00AENews.htm#anchor5301120.
S.R. Padgette N.B. Taylor D.L. Nida M.R. Bailey J. MacDonald L.R. Holden R.L. Fuchs (1996) ArticleTitleThe Composition of Glyphosate-Tolerant Soybean Seeds Is Equivalent to That of Conventional Soybeans J. Nutr. 126 702–716
B.P. Muller A. Zumdick I. Schuphan B. Schmidt (2001) ArticleTitleMetabolism of the Herbicide Glufosinate-Ammonium in Plant Cell Cultures of Transgenic (Rhizomania-Resistant) and Non-Transgenic Sugarbeet (Beta vulgaris), Carrot (Daucus carota), Purple Foxglove (Digitalis purpurea) and Thorn Apple (Datura Stramonium) Pest. Manag. Sci. 57 46–56
W.A. Pline A.J. Price J.W. Wilcut K.L. Edmisten R. Wells (2001) ArticleTitleAbsorption and Translocation of Glyphosate in Glyphosate-Resistant Cotton as Influenced by Application Method and Growth Stage Weed Sci. 49 460–467
T. Yamada T. Ishige N. Shiota H. Inui H. Ohkawa Y. Ohkawa (2002) ArticleTitleEnhancement of Metabolizing Herbicides in Young Tubers of Transgenic Potato Plants with the Rat CYP1A1 Gene Theor. Appl. Genet. 105 515–520
M. Bode P. Stobe B. Thiede I. Schuphan B. Schmidt (2004) ArticleTitleBiotransformation of Atrazine in Transgenic Tobacco Cell Culture Expressing Human P450 Pest. Manag. Sci. 60 49–58
R.L. Cooper J.M. Goldman T.E. Stoker (1999) ArticleTitleNeuroendocrine and Reproductive Effects of Contemporary-Use Pesticides Toxicol. Ind. Health 15 26–36
L.S. Birnbaum S.E. Fenton (2003) ArticleTitleCancer and Developmental Exposure to Endocrine Disruptors Environ. Health Perspect. 111 389–394
M. Bevan D. Shufflebottom K. Edwards R. Jefferson W. Schuch (1989) ArticleTitleTissue-and Cell-Specific Activity of a Phenylalanine Ammonia-Lyase Promoter in Transgenic Plants EMBO J. 8 1899–1906
R. Sevenier I.M. Meer Particlevan der R. Bino A.J. Koops (2002) ArticleTitleIncreased Production of Nutriments by Genetically Engineered Crops J. Am. Coll. Nutr. 21 199S–204S
M. Stobiecki I. Matysiak-Kata R. Franski J. Skala J. Szopa (2003) ArticleTitleMonitoring Changes in Anthocyanin and Ateroid Alkaloid Glycoside Content in Lines of Transgenic Potato Plants Using Liquid Chromatography/ Mass Spectrometry Phytochemistry 62 959–969
D. Burtin A.J. Michael (1997) ArticleTitleOverexpression of Arginine Decarboxylase in Transgenic Plants Biochem. J. 325 331–337
L. Bassie M. Noury O. Lepri T. Lahaye P. Christou T. Capell (2000) ArticleTitlePromoter Strength Influences Polyamine Metabolism and Morphogenic Capacity in Transgenic Rice Tissues Expressing the Oat adc cDNA Constitutively Transgenic Res. 9 33–42
Tsyrlin, V.A., Kuz’menko, N.V., and Pliss, M.G., The Role of Imidazolyl Receptors in the Circulation of the Blood (History and Current Idea), Vestn. Aritmologii, 2001, no. 21, pp. 92–97.
R. Nicoletti I. Venza G. Ceci M. Visalli D. Teti A. Reibaldi (2003) ArticleTitleVitreous Polyamines Spermidine, Putrescine, and Spermine in Human Proliferative Disorders of the Retina Br. J. Ophthalmol. 87 1038–1042
Bartoszewski, G., Malepszy, S., Smigocki, A.C., and Niemirowicz, K., Preliminary Characteristics of Transgenic Tomato (Lycopersicon esculentum Mill.) Plants with the Isopentyl Transferase Gene, TEKTRAN, Agricultural Research Service, 1998, http://www.nal.usda. gov/ttic/tektran/data//000009/46/0000094647.html
P.D. Fraser S. Romer C.A. Shipton P.B. Mills J.W. Kiano N. Misawa R.G. Drake W. Schuch P.M. Bramley (2002) ArticleTitleEvaluation of Transgenic Tomato Plants Expressing an Additional Phytoene Synthase in a Fruit-Specific Manner Proc. Natl. Acad. Sci. USA 99 1092–1097
G. Haberer J.J. Kieber (2002) ArticleTitleCytokinins: New Insights into a Classic Phytohormone Plant Physiol. 128 354–362
P. Redig T. Schmulling H. Onckelen Particlevan (1996) ArticleTitleAnalysis of Cytokinin Metabolism in ipt Transgenic Tobacco by Liquid Chromatography-Tandem Mass Spectrometry Plant Physiol. 112 141–148
B.K. Mookerjee J. Ballard C.J. Bentzel J.C. Allen C.Y. Jung (1979) ArticleTitleEffects of Plant Cytokinins on Human Lymphocyte Transformation J. Reticuloendothel. Soc. 25 299–314
K. Vermeulen M. Strnad V. Krystof L. Havlicek A. Aa Particlevan der M. Lenjou G. Nijs I. Rodrigus B. Stockman H. Onckelen Particlevan D.R. Bockstaele Particlevan Z.N. Berneman (2002) ArticleTitleAntiproliferative Effect of Plant Cytokinin Analogues with an Inhibitory Activity on Cyclin-Dependent Kinases Leukemia 16 299–305
D.L. Vesely J.L. Hudson J.L. Pipkin SuffixJr. L.D. Pack S.E. Meiners (1985) ArticleTitlePlant Growth-Promoting Hormones Activate Mammalian Guanylate Cyclase Activity Endocrinology 116 1887–1892
H.J. Heo S.C. Hong H.Y. Cho B. Hong H.K. Kim E.K. Kim D.H. Shin (2002) ArticleTitleInhibitory Effect of Zeatin, Isolated from Fiatoua villosa, on Acetylcholinesterase Activity from PC12 Cells Mol. Cells 13 113–117
G. Froldi U. Gallo E. Ragazzi L. Caparrotta (1999) ArticleTitle6-Benzylaminopurine: A Plant Derived Cytokinin Inducing Positive Inotropism by P2-Purinoceptors Planta Med. 65 245–249
A. Anand E.A. Schmelz S. Muthukrishnan (2003) ArticleTitleDevelopment of a Lesion-Mimic Phenotype in a Transgenic Wheat Line Overexpressing Genes for Pathogenesis-Related (PR) Proteins Is Dependent on Salicylic Acid Concentration Mol. Plant-Microbe Interact. 16 916–925
McKie, R., GM Corn Set to Stop Man Spreading His Seed, Guardian Unlimited, 2001, http://www.guardian. co.uk/gmdebate/Story/0.2763,549002.00.html.
M.W. Ho (2003) ArticleTitlePharmageddon Sci. Soc. 17 23–24
C.T. Lin W.H. Lin Y.L. Lyu J. Whang-Peng (2001) ArticleTitleInverted Repeats as Genetic Elements for Promoting DNA Inverted Duplication: Implications in Gene Amplification Nucleic Acids Res. 29 3529–3538
E.H. Chowdhury O. Mikami Y. Nakajima A. Hino H. Kuribara K. Suga M. Hanazumi C. Yomemochi (2003) ArticleTitleDetection of Genetically Modified Maize DNA Fragments in the Intestinal Contents of Pigs Fed Star-Link CBH351 Vet. Hum. Toxicol. 45 95–96
M.S. Khan P. Maliga (1999) ArticleTitleFluorescent Antibiotic Resistance Marker for Tracking Plastid Transformation in Higher Plants Nat. Biotechnol. 17 910–915
Konov, A.L., Biotechnology and the “Horizontal” Gene Carrying: Can One Eat Getenically Modified Products and Acquire the Resistance to Antibiotics? Ekologiya i Zhizn’, 2002, no. 2, pp. 66–68.
N.T. Perna G. Plunkett SuffixIII V. Burland B. Mau J.D. Glasner D.J. Rose G.F. Mayhew P.S. Evans J. Gregor H.A. Kirkpatrick G. Posfai J. Hackett S. Klink A. Boutin Y. Shao L. Miller E.J. Grotbeck N.W. Davis A. Lim E.T. Dimalanta K.D. Potamousis J. Apodaca T.S. Anantharaman J. Lin G. Yen D.C. Schwartz R.A. Welch F.R. Blattner (2001) ArticleTitleGenome Sequence of Enterohaemorrhagic Escherichia coli O157:H7 Nature 409 529–533
S. Bekal R. Brousseau L. Masson G. Prefontaine J. Fairbrother J. Harel (2003) ArticleTitleRapid Identification of Escherichia coli Pathotypes by Virulence Gene Detection with DNA Microarrays J. Clin. Microbiol. 41 2113–2125
J. Blahova K. Kralikova V. Krcmery K. Kubonova A. Vaculikova A. Mikovicova L. Klokocnikova J. Hanzen P. Jezek (2001) ArticleTitleTransferable Antibiotic Resistance in Multiresistant Nosocomial Acinetobacter baumannii Strains from Seven Clinics in the Slovak and Czech Republics J. Chemother. 13 143–147
K. Smalla H. Heuer A. Gotz D. Niemeyer E. Krogerrecklenfort E. Tietze (2000) ArticleTitleExogenous Isolation of Antibiotic Resistance Plasmids from Piggery Manure Slurries Reveals a High Prevalence and Diversity of IncQ-Like Plasmids Appl. Environ. Microbiol. 66 4854–4862
D. Jacob A. Lewin B. Meister B. Appel (2002) ArticleTitlePlant-Specific Promoter Sequences Carry Elements That Are Recognised by the Eubacterial Transcription Machinery Transgenic Res. 11 291–303
M.W. Ho A. Ryan J. Cummins (2000) ArticleTitleHazards of Transgenic Plants with the Cauliflower Mosaic Viral Promoter Microb. Ecol. Health Disease 12 6–11
Ho, M.W., Cummins, J., and Ryan, A., Cauliflower Transgenic Instability, ISIS Reprints, ISIS Publ., 2002, www.i-sis.org.uk.
J.C. Jennings D.C. Kolwyck S.B. Kays A.J. Whetsell J.B. Surber G.L. Cromwell R.P. Lirette K.C. Glenn (2003) ArticleTitleDetermining whether Transgenic and Endogenous Plant DNA and Transgenic Protein Are Detectable in Muscle from Swine Fed Roundup Ready Soybean Meal J. Animal Sci. 81 1447–1455
The United Kingdom Parliament: The Commons Hansard Written Answers Text for Wednesday 25 June dy2003, 2003, vol. 407, part 416, http://www.parliament.the-stationery-office.co.uk/pa/cm200203/cmhansrd// vo030625/index/30625-x.htm.
J.P. Nap P.L.J. Metz M. Escaler A.J. Conner (2003) ArticleTitleThe Release of Genetically Modified Crops into the Environment: 1. Overview of Current Status and Regulations Plant J. 33 1–18
A.J. Conner T.R. Glare J.P. Nap (2003) ArticleTitleThe Release of Genetically Modified Crops into the Environment: 2. Overview of Ecological Risk Assessment Plant J. 33 19–46
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Translated from Fiziologiya Rastenii, Vol. 52, No. 1, 2005, pp. 115–128.
Original Russian Text Copyright © 2005 by Kulikov.
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Kulikov, A.M. Genetically modified organisms and risks of their introduction. Russ J Plant Physiol 52, 99–111 (2005). https://doi.org/10.1007/s11183-005-0015-8
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DOI: https://doi.org/10.1007/s11183-005-0015-8