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Ozonolysis of Alkenes and Study of Reactions of Polyfunctional Compounds: LXVII. Synthesis of 27,27,27-Trifluoro-20-hydroxyecdysone Acetonides from 24,25- and 25,26-Anhydro-20-hydroxyecdysone Derivatives via Ozonolysis and Trifluoromethylation

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Abstract

Ozonolysis of 24,25/25,26-anhydro derivatives of 20-hydroxy-2,3:20,22-di-O-isopropylidene-ecdysone and 2,3-di-O-acetyl-20-hydroxy-20,22-O-isopropylideneecdysone, followed by trifluoromethylation of the corresponding 25-oxo derivatives afforded 2,3:20,22-di-O-isopropylidene- and 20,22-O-isopropylidene-27,27, 27-trifluoro-20-hydroxyecdysones.

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Authors and Affiliations

  1. Institute of Petroleum Chemistry and Catalysis, Academy of Sciences of Bashkortostan Republic, Russian Academy of Sciences, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075, Russia

    V. N. Odinokov, R. G. Savchenko, S. R. Afon’kina & L. M. Khalilov

  2. Ufa Research Center, Russian Academy of Sciences, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075, Russia

    V. N. Odinokov, R. G. Savchenko, S. R. Afon’kina & L. M. Khalilov

Authors
  1. V. N. Odinokov
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  2. R. G. Savchenko
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  3. S. R. Afon’kina
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  4. L. M. Khalilov
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__________

Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 3, 2005, pp. 387–395.

Original Russian Text Copyright © 2005 by Odinokov, Savchenko, Afon’kina, Khalilov.

For communication LXVI, see [1].

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Odinokov, V.N., Savchenko, R.G., Afon’kina, S.R. et al. Ozonolysis of Alkenes and Study of Reactions of Polyfunctional Compounds: LXVII. Synthesis of 27,27,27-Trifluoro-20-hydroxyecdysone Acetonides from 24,25- and 25,26-Anhydro-20-hydroxyecdysone Derivatives via Ozonolysis and Trifluoromethylation. Russ J Org Chem 41, 376–385 (2005). https://doi.org/10.1007/s11178-005-0173-3

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  • DOI: https://doi.org/10.1007/s11178-005-0173-3

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